Disitamab Vedotin With Pembrolizumab vs Chemotherapy in Previously Untreated Urothelial Cancer Expressing HER2
- Conditions
- Urothelial Carcinoma
- Interventions
- Registration Number
- NCT05911295
- Lead Sponsor
- Seagen, a wholly owned subsidiary of Pfizer
- Brief Summary
This study will enroll participants with urothelial cancer (UC). UC can include cancer of the bladder, kidney, or the tubes that carry pee through the body (ureter, urethra). This study will try to find out if the drugs disitamab vedotin with pembrolizumab works better than platinum-containing chemotherapy to treat patients with UC. This study will also test what side effects happen when participants take these drugs together. A side effect is anything a drug does to the body besides treating the disease.
Participants in this study will have cancer that has spread through the body (metastatic) or spread near where it started (locally advanced).
In this study, there are 2 different groups. Participants will be assigned to a group randomly. Participants in the disitamab vedotin arm will get the study drug disitamab vedotin once every two weeks and pembrolizumab once every 6 weeks. Participants in the standard of care arm will get gemcitabine once a week for 2 weeks with either cisplatin or carboplatin once every 3 weeks.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 400
- Histopathological confirmation of locally advanced unresectable or metastatic urothelial carcinoma (LA/mUC), including UC originating from the renal pelvis, ureters, bladder, or urethra.
- Measurable disease by investigator assessment per RECIST v1.1.
- Participant must not have received prior systemic therapy for LA/mUC. Exception will be made for neoadjuvant or adjuvant therapy, if disease recurrence/progression occurred more than 12 months after the last dose of therapy.
- Eligible to receive cisplatin- or carboplatin-containing chemotherapy.
- Able to provide archived formalin-fixed paraffin-embedded tumor tissue blocks from a muscle-invasive or metastatic UC lesion or biopsy of metastatic UC prior to treatment initiation. If archival tissue is not available a newly obtained baseline biopsy of an accessible tumor lesion is required within 28 days of cycle 1 day 1.
- HER2 expression of 1+ or greater on immunohistochemistry (IHC).
- Eastern Cooperative Oncology Group (ECOG) performance score of 0, 1, or 2 within 7 days prior to randomization.
-
Known hypersensitivity to disitamab vedotin, cisplatin, carboplatin, gemcitabine, or pembrolizumab or any of their components.
-
History of severe/life threatening immune-related adverse event (irAE) with PD-(L)1 inhibitors are excluded.
-
Central nervous system (CNS) and/or leptomeningeal metastasis. Participants with treated CNS metastases are permitted if all of the following are met.
- CNS metastases have been clinically stable for at least 4 weeks and baseline scans show no evidence of new or worsening CNS metastasis.
- Participant is on a stable dose of ≤ 10 mg/day of prednisone or equivalent for at least 2 weeks.
-
History of or active autoimmune disease that has required systemic treatment in the past 2 years.
-
Prior treatment with an agent directed to another stimulatory or co-inhibitory T cell receptor (including but not limited to CD137 agonists, CAR-T cell therapy, CTLA-4 inhibitors, or OX-40 agonists).
-
Prior solid organ or bone marrow transplantation.
-
Pleural effusion or ascites with symptoms or requiring symptomatic treatment.
-
Estimated life expectancy <12 week
-
Prior treatment with an MMAE agent or anti-HER2 therapy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Standard of care arm gemcitabine gemcitabine + cisplatin OR carboplatin Disitamab vedotin arm disitamab vedotin disitamab vedotin + pembrolizumab Disitamab vedotin arm pembrolizumab disitamab vedotin + pembrolizumab Standard of care arm carboplatin gemcitabine + cisplatin OR carboplatin Standard of care arm cisplatin gemcitabine + cisplatin OR carboplatin
- Primary Outcome Measures
Name Time Method Progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) by blinded independent central review (BICR) Approximately 3 years The time from randomization to first documentation of disease progression per RECIST v1.1 by BICR, or to death due to any cause.
Overall survival (OS) Approximately 5 years The time from date of randomization to date of death due to any cause.
- Secondary Outcome Measures
Name Time Method Number of electrocardiogram (ECG) abnormalities Through 30 days after the last study treatment; approximately 2 years Duration of Response (DOR) per RECIST v1.1 by BICR Approximately 3 years The time from first documented response of CR or PR (that is subsequently confirmed) to the first documented disease progression per RECIST v1.1, or to death due to any cause.
Control Rate (DCR) per RECIST v1.1 by BICR Approximately 3 years The proportion of participants with confirmed CR, PR, or stable disease according to RECIST v1.1.
Number of participants with adverse events (AEs) Through 30 days after the last study treatment; approximately 2 years Any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention.
Change from baseline to Week 16 in European Organization for Research and Treatment of Cancer core Quality of Life questionnaire (EORTC QLQ-C30) Global Health Status (GHS)/QoL Score Approximately 2 years The EORTC QLQ-C30 is used to evaluate health-related quality of life, functioning, disease symptoms, and treatment-related side effects. Scores range from 0-100. For GHS/QoL and functional scales, higher scores represent higher QoL or functioning. For symptom scales, higher scores represent more symptoms/worse status.
Objective response rate (ORR) per RECIST v1.1 by BICR Approximately 3 years The proportion of participants with confirmed complete response (CR) or partial response (PR) according to RECIST v1.1.
ORR per RECIST v1.1 by investigator assessment Approximately 3 years The proportion of participants with confirmed CR or PR according to RECIST v1.1.
DOR per RECIST v1.1 by investigator assessment Approximately 3 years The time from first documented response of CR or PR (that is subsequently confirmed) to the first documented disease progression per RECIST v1.1, or to death due to any cause.
DCR per RECIST v1.1 by investigator assessment Approximately 3 years The proportion of participants with confirmed CR, PR, or stable disease according to RECIST v1.1.
PFS per RECIST v1.1 by investigator assessment Approximately 3 years The time from randomization to first documentation of disease progression per RECIST v1.1, or to death due to any cause.
Change from baseline of left ventricular ejection fraction (LVEF) Through 2 years after last study treatment; approximately 4 years Time to pain progression Approximately 2 years The time from the date of randomization to whichever of the following occurs earlier:
* an increase in Numeric Rating Scale (NRS) for pain intensity of 2 points or more from baseline at 2 consecutive visits,
* an increase in number of opioid or analgesic use from baseline,
* or initiation of opioid or analgesic use. NRS for pain intensity asks participants to best describe their pain at its worst in the last 24 hours from 0 to 10. On the NRS, 0 means no pain and 10 means pain as bad as you can imagine.Number of participants with laboratory abnormalities Through 30 days after the last study treatment; approximately 2 years Treatment discontinuation rate due to AEs Approximately 2 years Time to Deterioration in EORTC QLQ-C30 GHS/QoL Score Approximately 2 years The time from the date of randomization to the date of first deterioration (change from baseline ≥10) in GHS/QoL score with no subsequent recovery. The EORTC QLQ-C30 is used to evaluate health-related quality of life, functioning, disease symptoms, and treatment-related side effects. Scores range from 0-100. For GHS/QoL and functional scales, higher scores represent higher QoL or functioning. For symptom scales, higher scores represent more symptoms/worse status.
Trial Locations
- Locations (307)
Foothill Cardioology
🇺🇸Arcadia, California, United States
Beverly Hills Multi-Specialties Practice
🇺🇸Beverly Hills, California, United States
Hospital Municipal de Morón. O. B. Lavignolle
🇦🇷Morón, Argentina
Centro de Investigacion Pergamino SA
🇦🇷Pergamino, Argentina
Banner Gateway Medical Center
🇺🇸Gilbert, Arizona, United States
Banner MD Anderson Cancer Center
🇺🇸Gilbert, Arizona, United States
UCLA Hematology/Oncology - Alhambra
🇺🇸Alhambra, California, United States
Comité Provincial de Bioética-Rosario
🇦🇷Rosario, Argentina
Providence Saint Joseph Medical Center
🇺🇸Burbank, California, United States
UCLA Burbank Cardiology
🇺🇸Burbank, California, United States
UCLA Hematology/Oncology - Burbank
🇺🇸Burbank, California, United States
UCLA Calabasas Specialty Care
🇺🇸Calabasas, California, United States
UCLA Encino Specialty Care (Radiology)
🇺🇸Encino, California, United States
UCLA Hematology/Oncology - Encino
🇺🇸Encino, California, United States
The Oncology Institute of Hope and Innovation
🇺🇸Whittier, California, United States
Foothill Cardiology Glendora
🇺🇸Glendora, California, United States
UCLA Downtown Los Angeles Primary & Specialty Care
🇺🇸Los Angeles, California, United States
Administrative Address: UCLA Hematology/Oncology
🇺🇸Los Angeles, California, United States
UCLA Cardiovascular Center
🇺🇸Los Angeles, California, United States
UCLA Hematology & Oncology Clinic
🇺🇸Los Angeles, California, United States
UCLA Hematology / Oncology
🇺🇸Los Angeles, California, United States
UCLA Westwood Specialty Care
🇺🇸Los Angeles, California, United States
UCLA Montecito Primary & Specialty Care
🇺🇸Montecito, California, United States
Pacific Cancer Care
🇺🇸Monterey, California, United States
Newport Diagnostics
🇺🇸Newport Beach, California, United States
Foothill Cardiology Pasadena
🇺🇸Pasadena, California, United States
Southern California Heart Specialists
🇺🇸Pasadena, California, United States
UCLA Porter Ranch Primary & Specialty Care
🇺🇸Porter Ranch, California, United States
UCSF Center at China Basin Imaging
🇺🇸San Francisco, California, United States
Helen Diller Family Comprehensive Cancer Center - Imaging Divisadero
🇺🇸San Francisco, California, United States
Helen Diller Family Comprehensive Cancer Center - Imaging Post
🇺🇸San Francisco, California, United States
UCSF Cancer Center MZ Phlebotomy
🇺🇸San Francisco, California, United States
UCSF Mount Zion Phlebotomy
🇺🇸San Francisco, California, United States
Helen Diller Family Comprehensive Cancer Center - Imaging Parnassus
🇺🇸San Francisco, California, United States
UCSF Parnassus Phlebotomy
🇺🇸San Francisco, California, United States
UCSF Parnassus-5 Lab
🇺🇸San Francisco, California, United States
Cardiovascular Care and Prevention Center at Mission Bay
🇺🇸San Francisco, California, United States
UCSF Investigational Drugs Pharmacy
🇺🇸San Francisco, California, United States
UCSF Mission Bay Gateway-2 Lab
🇺🇸San Francisco, California, United States
UCSF Mission Bay PCMB-5 Lab
🇺🇸San Francisco, California, United States
UCSF Mission Bay Pediatric Clinical Research Center
🇺🇸San Francisco, California, United States
UCSF Mission Bay Radiology and Nuclear Medicine
🇺🇸San Francisco, California, United States
University of California San Francisco
🇺🇸San Francisco, California, United States
University of California, San Francisco | HDFCCC - Hematopoietic malignancies
🇺🇸San Francisco, California, United States
Diagnostic Medical Group of Southern California, , San Gabriel, CA
🇺🇸San Gabriel, California, United States
Southern California Heart Centers
🇺🇸San Gabriel, California, United States
UCLA Hematology/Oncology - San Luis Obispo
🇺🇸San Luis Obispo, California, United States
Sierra Vista Regional Medical Center
🇺🇸San Luis Obispo, California, United States
UCLA Hematology/Oncology - Santa Barbara
🇺🇸Santa Barbara, California, United States
UCLA Hematology/Oncology - Santa Monica
🇺🇸Santa Monica, California, United States
UCLA Simi Valley Alamo Specialty Care
🇺🇸Simi Valley, California, United States
Twin Cities Community Hospital
🇺🇸Templeton, California, United States
UCLA Thousand Oaks Primary & Specialty Care
🇺🇸Thousand Oaks, California, United States
UCLA Hematology/Oncology - Torrance
🇺🇸Torrance, California, United States
UCLA Torrance Lomita Specialty Care
🇺🇸Torrance, California, United States
UCLA Santa Clarita Primary & Specialty Care
🇺🇸Valencia, California, United States
UCLA Ventura Cardiology
🇺🇸Ventura, California, United States
UCLA Hematology/Oncology - Westlake
🇺🇸Westlake Village, California, United States
Greater Baltimore Medical Center, Inc.
🇺🇸Baltimore, Maryland, United States
Greater Baltimore Medical Center
🇺🇸Baltimore, Maryland, United States
M Health Fairview Ridges Cancer Clinic
🇺🇸Burnsville, Minnesota, United States
Minnesota Oncology Hematology, PA
🇺🇸Woodbury, Minnesota, United States
Allina Health Cancer institute
🇺🇸Coon Rapids, Minnesota, United States
M Health Fairview Cancer Clinic-Edina
🇺🇸Edina, Minnesota, United States
Minnesota Oncology Hematology Pa
🇺🇸Edina, Minnesota, United States
M Health Fairview Maple Grove Cancer Center
🇺🇸Maple Grove, Minnesota, United States
M Health Fairview St. John's Hospital
🇺🇸Maplewood, Minnesota, United States
Minnesota Oncology Hematology PA
🇺🇸Maplewood, Minnesota, United States
Allina Health Cancer Institute (Virginia Piper Cancer Institute)
🇺🇸Minneapolis, Minnesota, United States
Allina Health Cancer Institute-United(VPCI)
🇺🇸Saint Paul, Minnesota, United States
Minnesota Oncology Hematology P.A.
🇺🇸Minneapolis, Minnesota, United States
Hennepin Country Medical Center
🇺🇸Minneapolis, Minnesota, United States
M Health Fairview University of Minnesota Investigational Drug Services
🇺🇸Minneapolis, Minnesota, United States
North Memorial Health Cancer Center
🇺🇸Robbinsdale, Minnesota, United States
HealthPartners Institute
🇺🇸Saint Louis Park, Minnesota, United States
Metro Minnesota Community Oncology Research Consortium(MMCORC)
🇺🇸Saint Louis Park, Minnesota, United States
Park Nicollet Frauenshuh Cancer Center
🇺🇸Saint Louis Park, Minnesota, United States
Regions Hospital
🇺🇸Saint Paul, Minnesota, United States
M Health Fairview Lakes Medical Center
🇺🇸Wyoming, Minnesota, United States
Nebraska Medicine- Bellevue Medical Center
🇺🇸Bellevue, Nebraska, United States
Nebraska Medicine -Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
Nebraska Medicine-Cancer Center at Village Pointe Health Center
🇺🇸Omaha, Nebraska, United States
The University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
Optum Care Cancer Care at Seven Hills
🇺🇸Las Vegas, Nevada, United States
OptumCare Cancer center
🇺🇸Las Vegas, Nevada, United States
OptumCare Cancer Center Care at Fort Apache
🇺🇸Las Vegas, Nevada, United States
Icahn School of Medicine at Mount Sinai
🇺🇸New York, New York, United States
Ship study drug to: Mount Sinai Hospital- Pharmacy Dept
🇺🇸New York, New York, United States
ECU Health Medical Center
🇺🇸Greenville, North Carolina, United States
AHN Saint Vincent Hospital
🇺🇸Erie, Pennsylvania, United States
AHN Jefferson Hospital
🇺🇸Jefferson Hills, Pennsylvania, United States
AHN Forbes Hospital
🇺🇸Monroeville, Pennsylvania, United States
Allegheny Valley Hospital
🇺🇸Natrona Heights, Pennsylvania, United States
AHN Cancer Institute - Allegheny General Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
AHN Cancer Institute Pharmacy
🇺🇸Pittsburgh, Pennsylvania, United States
AHN West Penn Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
UT Southwestern Medical Center - Redbird
🇺🇸Dallas, Texas, United States
University of Texas Southwestern Medical Center - Simmons Cancer Center
🇺🇸Dallas, Texas, United States
University of Texas Southwestern Medical Center-Simmons Cancer Center Pharmacy
🇺🇸Dallas, Texas, United States
University of Texas Southwestern Medical Center
🇺🇸Dallas, Texas, United States
UT Southwestern - Simmons Cancer Center - Fort Worth
🇺🇸Fort Worth, Texas, United States
UT Southwestern - Simmons Cancer Center - Richardson/Plano
🇺🇸Richardson, Texas, United States
Inova Schar Cancer Institue Infusion Pharmacy
🇺🇸Fairfax, Virginia, United States
Inova Schar Cancer Institute
🇺🇸Fairfax, Virginia, United States
Harborview Medical Center
🇺🇸Seattle, Washington, United States
Fred Hutchinson Cancer Center.
🇺🇸Seattle, Washington, United States
University of Washington Medical Center
🇺🇸Seattle, Washington, United States
Clinica Viedma
🇦🇷Viedma, RIO Negro, Argentina
Fundación Dr. Ruben Kowalyszyn
🇦🇷Viedma, RÍO Negro, Argentina
Comisión Provincial de Evaluación de Proyectos de Investigación en Salud Humana (CEEPISH)
🇦🇷Viedma, RÍO Negro, Argentina
SIPROSA - Sistema Provincial de Salud
🇦🇷San Miguel de Tucumán, Tucumán, Argentina
Centro de Oncologia e Investigacion de Buenos Aires (COIBA)
🇦🇷Berazategui, Argentina
Instituto Médico Especializado Alexander Fleming
🇦🇷Buenos Aires, Argentina
CEMIC - Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno
🇦🇷Buenos Aires, Argentina
Centro Medico Austral
🇦🇷Buenos Aire, Argentina
Centro Oncologico Korben
🇦🇷Buenos Aire, Argentina
Fundacion Cenit
🇦🇷Caba, Argentina
Investigaciones Clinicas Moleculares (ICM)
🇦🇷Caba, Argentina
CEMAIC - Centro Medico Privado
🇦🇷Cordoba, Argentina
Sanatorio Parque
🇦🇷Rosario, Argentina
Consultorio Dr. Miguel Angel Escudero
🇦🇷Salta, Argentina
Oncologia Salta
🇦🇷Salta, Argentina
Centro para la Atencion Integral del paciente Oncologico
🇦🇷Tucuman, Argentina
Concord Repatriation General Hospital
🇦🇺Concord, New South Wales, Australia
Saint Vincents Hospital Sydney - Human Research Ethics Committee
🇦🇺Darlinghurst, New South Wales, Australia
St Vincent's Clinic
🇦🇺Darlinghurst, New South Wales, Australia
Macquarie University Hospital
🇦🇺Macquarie University, New South Wales, Australia
Macquarie University
🇦🇺North Ryde, New South Wales, Australia
Prince of Wales Hospital
🇦🇺Randwick, New South Wales, Australia
North Shore Private Hospital
🇦🇺St Leonards, New South Wales, Australia
Mater Misericordiae - Mater Hospital Brisbane
🇦🇺Brisbane, Queensland, Australia
Icon Cancer Centre Chermside
🇦🇺Herston, Queensland, Australia
Mater Research
🇦🇺South Bribane, Queensland, Australia
Bellberry Limited
🇦🇺Eastwood, South Australia, Australia
Peninsula & South Eastern Hematology and Oncology Group (PASO)
🇦🇺Frankston, Victoria, Australia
South Eastern Sydney Local Health District
🇦🇺Caringbah, Australia
Lyell McEwin Hospital
🇦🇺Elizabeth Vale, Australia
Peninsula And South East Oncology
🇦🇺Frankston, Australia
Cabrini.
🇦🇺Malvern, Australia
Mid North Coast Local Health District
🇦🇺NSW, Australia
Port Macquarie Base Hospital
🇦🇺Port Macquarie, Australia
Mater Cancer Care Centre
🇦🇺South Brisbane, Australia
Royal North Shore Hospital
🇦🇺St Leonards, Australia
Algemeen Ziekenhuis Maria Middelares
🇧🇪Gent, Belgium
AZ St. Lucas
🇧🇪Ghent, Belgium
University Hospital Ghent
🇧🇪Ghent, Belgium
CHU UCL Namur-Site de Saint Elisabeth
🇧🇪Namur, Belgium
GZA Hospital Sint-Augustinus
🇧🇪Wilrijk, Belgium
Centro de Oncologia da Bahia
🇧🇷Salvador, BA, Brazil
Suporte Nutricional e Quimioterapia - PRONUTRIR
🇧🇷Fortaleza, Ceará, Brazil
Associacao Mario Penna - Hospital Luxemburgo - NEPI Nucleo de Ensino Pesquisa e Inovacao
🇧🇷Belo Horizonte, MG, Brazil
Hospital Sao Vicente de Paulo
🇧🇷Passo Fundo, RIO Grande DO SUL, Brazil
Hospital Mae de Deus
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS)
🇧🇷Porto Alegre, RS, Brazil
Hospital Nossa Senhora da Conceicao / Grupo Hospitalar Conceicao
🇧🇷Porto Alegre, RS, Brazil
Fundacao Doutor Amaral Carvalho
🇧🇷Jaú, SÃO Paulo, Brazil
Hospital de Cancer de Barretos - Fundacao Pio XII
🇧🇷Barretos, Brazil
Erasto Gaertner Hospital
🇧🇷CuriBba, Brazil
Hospital Alemao Oswaldo Cruz
🇧🇷Sao Paulo, Brazil
Arthur J.E. Child Comprehensive Cancer Centre
🇨🇦Calgary, Alberta, Canada
University of Alberta / Cross Cancer Institute
🇨🇦Edmonton, Alberta, Canada
Lakeridge Health - The R.S. McLaughlin Durham Regional Cancer Centre (MDRCC)
🇨🇦Oshawa, Ontario, Canada
Princess Margaret Cancer Centre - University Health Network
🇨🇦Toronto, Ontario, Canada
Centro de Oncología de Precisión
🇨🇱Los Condes, Region Metropolitana Santiago, Chile
Centro de Estudios Clínicos SAGA
🇨🇱Santiago, Chile
Centro de Investigaciones Clinicas Vina del Mar
🇨🇱Vina del mar, Chile
Fakultni nemocnice Hradec Kralove
🇨🇿Hradec Kralove, Hradec Králové, Czechia
Fakultni Nemocnice Olomouc (Fnol) - Onkologicka Klinika
🇨🇿Olomouc, Czechia
University Hospital of Besancon
🇫🇷Besancon, France
Institut Bergonié Centre de Lutte Contre le Cancer (CLCC)
🇫🇷Bordeaux Cedex, France
Centre de Lutte contre le Cancer - François Baclesse
🇫🇷Caen Cedex 5, France
Institut Paoli Calmettes
🇫🇷Marseille, France
Institut régional du Cancer de Montpellier - ICM Val d'Aurelle
🇫🇷MONTPELLIER Cedex 5, France
Pharmacy ICM Val d'Aurelle - Bat A - Rez-de-Jardin
🇫🇷MONTPELLIER Cedex 5, France
Centre de Lutte contre le Cancer (CLCC) - Centre Antoine Lacassagne
🇫🇷Nice Cedex 2, France
Hopital Europeen Georges Pompidou
🇫🇷Paris, France
Hospices Civils de Lyon
🇫🇷Pierre Benite, France
Unite de Coordination de la Biologie des Essais Cliniques
🇫🇷Strasbourg, France
Institut de Cancerologie Strasbourg Europe
🇫🇷Strasbourg, France
Institut Gustave Roussy
🇫🇷Villejuif Cedex, France
Metropolitan General Hospital
🇬🇷Cholargos, Greece
Cancer Trials Cork
🇮🇪Cork, Ireland
Tallaght University Hospital
🇮🇪Tallaght, Ireland
Cork University Hospital
🇮🇪Wilton, Ireland
Shaare Zedek Medical Center
🇮🇱Jerusalem, Other, Israel
Hadassah Medical Center
🇮🇱Jerusalem, Other, Israel
Sheba Medical Center.
🇮🇱Ramat Gan, Other, Israel
Emek Medical Center
🇮🇱Afula, Israel
Soroka Medical Center
🇮🇱Be'er Sheva, Israel
Rambam Health Care Campus
🇮🇱Hafia, Israel
Rambam Health Corp.
🇮🇱Haifa, Israel
Meir Medical Center
🇮🇱Kefar Sava, Israel
Rabin Medical Center
🇮🇱Petach Tikva, Israel
Sheba Medical Center
🇮🇱Ramat Gan, Israel
The Chaim Sheba Medical Center
🇮🇱Ramat Gan, Israel
Kaplan Medical Center
🇮🇱Rehovot, Israel
Tel Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel
IRCCS Istituto Tumori Giovanni Paolo II
🇮🇹Bari, Apulia, Italy
Azienda Ospedaliera Cardinale Giovanni Panico
🇮🇹Tricase, Apulia, Italy
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale.
🇮🇹Napoli, Campania, Italy
Oncologia Medica, Ospedale Civile S. Maria delle Croci
🇮🇹Ravenna, Emilia-romagna, Italy
Ospedale Policlinico San Martino
🇮🇹Genova, Liguria, Italy
Ospedale San Raffaele
🇮🇹Milano, Lombardy, Italy
Istituto Clinico Humanitas-Humanitas Cancer Center
🇮🇹Rozzano (Milano), Lombardy, Italy
IRCCS Istituto Clinico Humanitas
🇮🇹Rozzano, Milano, Italy
IRCCS - Ospedale San Raffaele
🇮🇹Milano, Milan, Italy
Azienda Sanitaria Locale Napoli 2 Nord
🇮🇹Giugliano in Campania, Naples, Italy
P.O. "S. Maria Delle Grazie" - Pozzuoli - ASL Napoli Nord 2
🇮🇹Pozzuoli (NA), Other, Italy
ASL-AT, Ospedale Cardinal Massaia di Asti
🇮🇹Asti, Piemonte, Italy
SOSD Farmacia Ospedaliera
🇮🇹Aviano, Pordenone, Italy
Centro di Riferimento Oncologico Di Aviano
🇮🇹Aviano, Pordenone, Italy
AUSL Romagna - Presidio Ospedale "Umberto I" di Lugo
🇮🇹Lugo, Ravenna, Italy
AUSL della Romagna - Ospedale degli infermi
🇮🇹Faenza, RA, Italy
Azienda Ospedaliero Universitaria Careggi
🇮🇹Firenze, Tuscany, Italy
Azienda Ospedaliera S. Maria di Terni
🇮🇹Terni, Umbria, Italy
ASL Asti - Ospedale Cardinal Massaia - S.C. Farmacia Ospedaliera
🇮🇹Asti, Italy
ASST Cremona Farmacia Ospedaliera
🇮🇹Cremona, Italy
U.O. Farmacia Ospedaliera a Politiche del Farmaco Az. Osp. Universitaria Careggi
🇮🇹Firenze, Italy
Ospedale Policlinico San Martino Farmacia
🇮🇹Genova, Italy
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale
🇮🇹Napoli, Italy
Istituto Nazionale Tumori IRCCS Fondazione Giovanni Pascale
🇮🇹Napoli, Italy
Istituto Oncologico Veneto - IRCCS
🇮🇹Padova, Italy
Azienda Ospedaliera Universitaria Pisana Ospedale Santa Chiara
🇮🇹Pisa, Italy
Azienda Ospedaliera Universitaria Pisana, U.O. Farmacia Ospedaliera
🇮🇹Pisa, Italy
Policlinico Universitario Agostino Gemelli
🇮🇹Roma, Italy
Centro Ricerche Cliniche Di Verona Srl
🇮🇹Verona, Italy
Azienda Ospedaliera Universitaria Integrata di Verona
🇮🇹Verona, Italy
National Hospital Organization Kyushu Cancer Center
🇯🇵Fukuoka-shi, Fukuoka, Japan
Gunma Prefectural Cancer Center
🇯🇵Ota-Shi, Gunma, Japan
Kobe University Hospital
🇯🇵Kobe-shi, Hyogo, Japan
Yokohama City University Medical Center
🇯🇵Yokohama, Kanagawa, Japan
Osaka University Hospital
🇯🇵Suita-shi, Osaka-fu, Japan
Osaka University Hopsital
🇯🇵Suita-city, Osaka, Japan
Tokushima University Hospital
🇯🇵Tokushima-Shi, Tokushima, Japan
Chiba Cancer Center
🇯🇵Chiba, Japan
National Hospital Organization Kumamoto Medical Center
🇯🇵Kumamoto, Japan
Osaka Prefectural Hospital Organization - Osaka International Cancer Institute
🇯🇵Osaka, Japan
Yamagata University Hospital
🇯🇵Yamagata, Japan
National Cancer Center
🇰🇷Goyang-si, Gyeonggi-do, Korea, Republic of
CHA Bundang Medical Center, CHA University
🇰🇷Seongnam-si, Gyeonggi-do, Korea, Republic of
The Catholic University of Korea, St. Vincent's Hospital
🇰🇷Suwon-si, Gyeonggi-do, Korea, Republic of
Jeonbuk National University Hospital
🇰🇷Jeonju-si, Jeollabuk-do, Korea, Republic of
Chonbuk National University Hospital
🇰🇷Jeonju-si, Jeollabuk-do, Korea, Republic of
Chonnam National University Hwasun Hospital
🇰🇷Hwasun-gun, Jeollanam-do, Korea, Republic of
Wonkwang University Hospital
🇰🇷Iksan-si, Jeonlabuk-do, Korea, Republic of
Inje University Haeundae Paik Hospital
🇰🇷Busan, Korea, Republic of
Kosin University Gospel Hospital
🇰🇷Busan, Korea, Republic of
Gachon University Gil Medical Center
🇰🇷Incheon, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Korea, Republic of
Korea University Anam Hospital
🇰🇷Seoul, Korea, Republic of
Kangbuk Samsung Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Asan Medical Center - Oncology
🇰🇷Seoul, Korea, Republic of
Rijnstate Hospital
🇳🇱Arnhem, Netherlands
Akershus universitetssykehus HF
🇳🇴Lørenskog, Akershus, Norway
Avdeling for blod og kreft sykdommer. Stavanger universitetssykehus
🇳🇴Stavanger, Norway
Hospital Militar Central Coronel Luis Arias Schreiber
🇵🇪Lima, Peru
Hospital Maria Auxiliadora
🇵🇪Lima, Peru
Hospital de Braga
🇵🇹Braga, Portugal
Centro Clinico Champalimaud
🇵🇹Lisboa, Portugal
Hospital de Santa Maria - Centro Hospitalar Universitario Lisboa Norte
🇵🇹Lisboa, Portugal
Champalimaud Clinical Center
🇵🇹Lisbon, Portugal
Centro Hospitalar Universitário de São João
🇵🇹Porto, Portugal
National University Hospital
🇸🇬Singapore, Singapore
National University Cancer Institute
🇸🇬Singapore, Singapore
National Cancer Centre Singapore
🇸🇬Singapore, Singapore
Raffles Hospital
🇸🇬Singapore, Singapore
Complejo Hospitalario Universitario de Santiago
🇪🇸Santiago de Compostela, A Coruna, Spain
Farmacia Oncologica - Unidad de Ensayos Clinicos
🇪🇸Santiago de Compostela, A Coruna, Spain
Institut Catala d' Oncologia de Badalona - Hospital Universitari Germans Trias i Pujos
🇪🇸Badalona, Barcelona, Spain
Institut Catala d'Oncologia Badalona (ICO Badalona) - Hospital Universitari Germans Trias i Pujol
🇪🇸Badalona, Barcelona, Spain
Institut Catala d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet)
🇪🇸L'Hospitalet de Llobregat, Barcelona, Spain
Hospital Universitario Marques de Valdecilla
🇪🇸Santander, Cantabria, Spain
Hospital Universitario Puerta de Hierro - Majadahonda
🇪🇸Majadahonda, Madrid, Spain
Hospital del Mar
🇪🇸Barcelona, Spain
Hospital Universitari Vall D Hebron
🇪🇸Barcelona, Spain
Hospital Universitari Vall d'Hebron
🇪🇸Barcelona, Spain
Hospital Clinic de Barcelona
🇪🇸Barcelona, Spain
Hospital de la Santa Creu i Sant Pau- Pharmacy
🇪🇸Barcelona, Spain
Hospital de La Santa Creu i Sant Pau
🇪🇸Barcelona, Spain
Unitat d'Assajos Clinics Servei de Farmacia
🇪🇸L'Hospitaler De Llobregat, Spain
Hospital General Universitario Gregorio Maranon
🇪🇸Madrid, Spain
MD Anderson Cancer Center Madrid
🇪🇸Madrid, Spain
Hospital Universitario Ramon y Cajal
🇪🇸Madrid, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Hospital Universitario La Paz: Servicio de Farmacia
🇪🇸Madrid, Spain
Hospital Universitario La Paz
🇪🇸Madrid, Spain
HM Centro Integral Oncologico Clara Campal
🇪🇸Madrid, Spain
Hospital Universitario HM Sanchinarro
🇪🇸Madrid, Spain
Complejo Hospitalario Universitario de Ourense (CHOU)
🇪🇸Ourense, Spain
Uppsala University Hospital (Akademiska Sjukhuset)
🇸🇪Uppsala, Uppland, Sweden
Ryhov Hospital
🇸🇪Jonkoping, Sweden
Karolinska University Hospital
🇸🇪Stockholm, Sweden
Kaohsiung Medical University Hospital
🇨🇳Kaohsiung, Taiwan
China Medical University Hospital - Pharmacy
🇨🇳Taichung, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
Taichung Veterans General Hospital Clinical Trials Pharmacy
🇨🇳Taichung, Taiwan
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
Chi Mei Hospital liouying
🇨🇳Tainan City, Taiwan
Clinical Trial Pharmacy, Department of Pharmacy, National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan
National Cheng-Kung University Hospital
🇨🇳Tainan, Taiwan
National Taiwan University Hospital, Investigational Drug Service
🇨🇳Taipei, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Barts Health NHS Trust Saint Bartholomews Hospital
🇬🇧London, United Kingdom
Guy's and St Thomas' NHS Foundation Trust
🇬🇧London, United Kingdom
Guy's and St Thomas' NHS Foundation
🇬🇧London, United Kingdom