Determination of Genetic Susceptibility in Severe Recurrences of Ocular Toxoplasmosis

Not Applicable

Terminated

• Conditions: Toxoplasmosis Infection; Genotype II; Ocular Toxoplasmosis With Recurrences
• Interventions: Biological: seropositive for Toxoplasma gondii

• Registration Number: NCT02863588
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Ocular toxoplasmosis (OT) is a major cause of visual impairment worldwide. OT is responsible for 30 to 50% of posterior uveitis. It is characterized by dormant infections that may reactivate without known reasons, causing severe irreversible visual loss. The overall recurrence rate of OT in Europe is greater than 80% for patients and may range from one episode to 11 episodes (1% of OT) in the most extreme cases. Current treatments do not reduce the risk of recurrences and the risk of toxoplasmosis recurrence cannot be predicted in these immunocompetent patients. These clinical and biological expression changes might be related to an individual genetic susceptibility of each patient. The advanced analysis of the entire genome now possible to consider the project.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-08-08
• Study First Submitted QC: 2016-08-08
• Study First Posted: 2016-08-11
• Study Start: 2017-03-30
• Primary Completion: 2019-11-11
• Study Completion: 2019-11-11
• Status Verified: 2021-08
• Last Update Submitted: 2021-08-31
• Last Update Posted: 2021-09-08

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• seropositive for Toxoplasma gondii (for patient and parents)
• Infection with genotype II (for patient and parents)
• ocular toxoplasmosis recurrences >5 (patients only)

Exclusion Criteria

• Parents seronegative for T. gondii infection
• Infection with others genotypes than type II

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
seropositive for Toxoplasma gondii	seropositive for Toxoplasma gondii	-

Primary Outcome Measures

Name	Time	Method
Highlighting of genetic mutations associated with the susceptibility to Toxoplasma gondii.severe eye recurrences. Mutation analysis will be done by exome sequencing of the subjects included in this study	This analysis will be performed on a blood sample taken in patients included in the inclusion visit

Trial Locations

Locations (1)

University Hospital, Strasbourg, france; 🇫🇷 Strasbourg, France