Effect of Endurance Training-Induced Coenzyme Q10 (CoQ10) Supplementation on Myokine, Exerkine Secretion and Cognitive Functions in Long-Distance Runners
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 发起方
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Change in cognitive funtions as a result of CoQ10 supplementation measured via cogntitive function test.
研究概览
简要总结
The goal of this clinical trial is to learn if CoQ10 amplifies endurance training-induced myokine and exerkine secretion and if those changes influences cognition in long-distance runners.
Does 4-week high-dosage CoQ10 supplementation increase the secretion of myokine, exerkine sercetion? Does the above-mentioned intervention improve the cognitive function in long distance runners?
Participants will:
Take CoQ10 or a placebo every day for 4 weeks. Visit the laboratory once every 4 weeks for checkups and tests. Keep the participants' food and training diary.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 30 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •training experienced for minimum 2 years
- •running training at least 2 times per week
- •Personal Best on 10k (<50 minutes)
排除标准
- •taking supplements which can interrupt primary outcomes (vitamin D, omega-3 fatty acids)
- •injured in last 6 months to avoid n number reduction
结局指标
主要结局
Change in cognitive funtions as a result of CoQ10 supplementation measured via cogntitive function test.
时间窗: The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10
The investigators assume that supplementation with CoQ10 will change cognition (measured via cognitive function tests - Stroop Test, Trial Making Test A and Trial Making Test B) in long-distance runners. The results will be obtained as time (seconds) needed to complete tasks while testing.
Change in myokine and exerkine concentration in the blood plasma as a result of CoQ10 supplementation.
时间窗: The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10
The investigators will assess the concentration of blood myokine and exerkine concentration (pg or ug/dl) of blood plasma using the colorimetric method.
次要结局
- Change in aerobic capacity measured via direct test to volitional exhaustion on a motorized treadmill(The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10)