Effects of Endurance Training Intensity on Exercise Capacity, Body Composition, and Appetite Regulation in Cystic Fibrosis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cystic Fibrosis
- Sponsor
- University of Kiel
- Enrollment
- 70
- Locations
- 2
- Primary Endpoint
- change body fat mass index
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
Aim of the randomized controlled trial is to investigate the effects of endurance training with different intensities on physical performance, body composition and appetite regulation in people with cystic fibrosis.
Investigators
Prof. Dr. Dr. Anja Bosy-Westphal
Prof. Dr. Dr. Anja Bosy-Westphal
University of Kiel
Eligibility Criteria
Inclusion Criteria
- •confirmed diagnosis of cystic fibrosis by at least 2 sweat tests and / or by the presence of two CF mutations,
- •willingness to participate in and to comply with the research project procedure,
- •written informed consent of patients,
- •age ≥ 18 years,
- •FEV1 of pred. ≥ 40%,
- •Stable condition (as indicated by absence of one or more signs: new or increased haemoptysis, increased malaise, fatigue or lethargy, temperature over 38°C, weight loss, sinus pain and a decrease in pulmonary function by 10% or more)
Exclusion Criteria
- •Severe pulmonary exacerbation,
- •cor pulmonale,
- •musculoskeletal discomfort that makes a regular exercise training impossible,
- •untreated CF-related diabetes
Outcomes
Primary Outcomes
change body fat mass index
Time Frame: at baseline and after 4 weeks of exercise training program
measured with body fat mass index (FMI) in kg / m\*2
change in Body fat free mass index
Time Frame: at baseline and after 4 weeks of exercise training program
measured with fat free body mass index (FFMI) in kg / m\*2
change in Peak Oxygen Uptake
Time Frame: at baseline and after 4 weeks of exercise training program
measured with peak Oxygen uptake (VO2) in percent predicted
change in Peak Workload
Time Frame: at baseline and after 4 weeks of exercise training program
measured with peak Workload in percent predicted
Secondary Outcomes
- change in Forced Expiratory Volume in 1 second(at baseline and after 4 weeks of exercise training program)
- appetite control - subjective feeling of hunger(at baseline and after 4 weeks of exercise training program)
- change in Health related quality of life(at baseline and six and twelve months after completion of exercise training program)