the role of risk factors on the host-pathogen interactions in melioidosis

• Conditions: Burkholderia pseudomallei infection; Melioidosis; 10019815; 10027665

• Registration Number: NL-OMON51780
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 140

Inclusion Criteria

adult patient with one of the following comorbidities:
- Type II Diabetes (8% (182 mg/dL) < HBA1c >=8.0% (183 mg/dL);poorly
controlled),
- HIV-1 (200<= CD4 count >200),
- Renal failure (eGFR < 30 or on dialysis)
- Liver failure (Child-Pugh score A,B or C)
- Thalassaemia (with and without iron overload)
- COPD (2 < GOLD > 3/4).

Exclusion Criteria

Patients < 18 years. Patients with immunosuppressive medication, a recent
infectious syndrome, or recent vaccination (within 30 days) will not be
included.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>We will outline the differences in macrophage function, specifically<br /><br>phagocytosis, bacterial killing, and cytokine response, in those at higher risk<br /><br>of acquisition due to underlying comorbidities in melioidosis.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To delineate the underlying processes, such as gene expression and<br /><br>immuno-metabolic profiles, to understand altered macrophage function.</p><br>