The Correlation Between Hair Cortisol Level of Acute Stroke or Its Long Term Disability.
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- INL-6
研究概览
简要总结
In patients admitted to hospital with acute cerebrovascular stroke, we want to study the relationship between hair cortisol levels and biomarkers of inflammation and the clinical and radiological severity of the stroke and the degree of neurological disability being tested in three months and one year after.
详细描述
The study will include patients hospitalized due to an acute cerebrovascular stroke. A number of 30 patients aged 40-70 will be included. Within 48 hours of the event, blood inflammatory biomarkers, and scalp hair sample for cortisol will be taken. All recruited patients will undergo full neurological examination and the severity of the stroke will be rated using NIHSS (National Institutes of Health Stroke Scale). 3 months and one year later neurological examination and rating of neurological disability will be determined using Rankin Scale.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 40-
- •Acute cerebrovascular stroke (symptoms that began no more than 72 hours before)
- •Rankin 0-1 before the event
- •Exclusion criteria:
- •Suspicion or known Cushing's syndrome
- •Known adrenal failure
- •Chronic inflammatory disease
- •Active malignancy
- •Acute infectious disease within 4 months before enrollment
排除标准
- 未提供
结局指标
主要结局
INL-6
时间窗: 24 months
single blood sample will be drawn to measure INL-6 levels.
Hair Cortisol level
时间窗: 24 months
single hair sample will be drawn to measure cortisol levels (mcg/dl)
Anti Tumor Necrosis Factor alpha
时间窗: 24 months
single blood sample will be drawn to measure Anti Tumor Necrosis Factor alpha levels (pg/ml).
C-reactive protein levels
时间窗: 24 months
single blood sample will be drawn to measure c-reactive protein levels (mcg/dl).
次要结局
- Cortisol(24 months)
- FT3(24 months)
- TSH(24 months)
- FT4(24 months)