Status, Volatility and development of skin microbiome in acne vulgaris and the effect of live skin bacteria on acne prone ski

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 14

Inclusion Criteria

Healthy female and male volunteers,
- Age 16 - 23 years
- Subjects with skin prone to acne and lesions up to grade 4 on the Leeds scale.
- Subjects who are free of anti-acne or antiseborrheic topical medical treatments until at least 2 weeks before the start of the study.
- subjects without topical retinoid treatment, for at least 2 weeks before the start of the study
- subjects who did not receive oral retinoid therapy for at least two months prior to the start of the study
- subjects without topical and oral antibiotic treatment for at least 4 weeks prior to the start of the study
- Subjects who are willing to cooperate and comply with the following requirements for the duration of the study:
- Use only the products provided on the face to replace their usual facial care products;
- Use make-up products for lips and eyes only.
- Do not manipulate the lesions (press, try to soft, etc.)
- Do not use peeling products on the face
- Subjects who are willing to report unwanted symptoms immediately
- Test persons who are able to read, understand and consent in writing
- subjects with constant contraception for at least 3 months before the start of the study and no planned change during the study
- test persons who are willing to refrain from swimming in chlorinated water

Exclusion Criteria

- Subjects who cannot follow the requirements of the protocol
- Subjects planning to participate in another study or participating in one
- subjects with severe inflammatory lesions, greater than Grade 4 of the Leeds Score
- subjects who have skin irritations or damages in the whole face (area with desquamation, dryness, skin picking etc.)
- Subjects who treat themselves aesthetically (peeling, etc.), aesthetic care by a cosmetician (deep skin cleansing) or aesthetic treatments by a dermatologist (dermabrasion, peeling, laser, etc.) during the study period and at least 2 months before the start of the study.
- Test persons who have a disease or skin disease which, in the doctor's opinion, excludes participation
- subjects with active or localized or systemic infection
- volunteers with atopic skin diseases (atopic dermatitis, eczema, etc ...) except seasonal allergies
- subjects under topical treatment with acne medication within the last 2 weeks
- volunteers, under systemic treatment with cyclins intrahlb of the last month
- subjects under isotretinoin treatment
- Probands with vitamin B complex intake
- Women with oral contraception within the last 3 months before the start of the study or who plan to change their contraception within the duration of the study.
- women undergoing anti-androgen hormonal treatment (cyproterone acetate, CMA and others) within the last 3 months before the start of the study
- Women who are pregnant, breastfeeding or planning to become pregnant within 6 months.
- Men with a lot of facial hair and a full beard
subjects currently taking medication (e.g., oral or topical steroids, anti-inflammatory drugs) or either topical prescription drugs and / or over-the-counter (OTC) facial skin treatments
- Subjects who do not want to be photographed
subjects with a known allergy or hypersensitivity to any of the components of the test product

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method

Secondary Outcome Measures

Name	Time	Method

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