MRI Biomarkers of Effective Tissue Reperfusion After Thrombectomy of an Acute Proximal Occlusion of the Anterior Circulation: MR-Reperfusion Longitudinal Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Description of MRI biomarkers (volume, location of the infarction and penumbra; collateral circulation; location, length of the thrombus; trans-cerebral, cortical venous changes) in patients with ischemic stroke successfully treated by thrombectomy
研究概览
简要总结
Cerebral infarction by proximal occlusion of the anterior circulation is common with major personal and societal consequences.
MRI is the gold standard for exploring stroke, especially ischemic, and a number of biomarkers on initial MRI (before reperfusion) are predictive of neurological prognosis. However, their spatiotemporal evolution in the suites of reperfusion is unclear.
Close monitoring by MRI would make it possible to precisely know the tissue, vascular and microvascular evolution of the infarct area and the penumbra after reperfusion, and thus to characterize MRI biomarkers associated with efficient tissue reperfusion.
The aim of the MR-Reperfusion study is to characterize new MRI biomarkers of efficient tissue reperfusion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •To be over 18 year-old
- •Perfusion MRI assessment on admission;
- •Admission for an acute infarction of the anterior circulation with proximal occlusion (tandem, distal internal carotid, or M1 segment of the middle cerebral artery);
- •Initial mTICI = 0-1 on the initial angiography before treatment;
- •Patient in complete autonomy (mRS ≤ 2) before the onset of symptoms;
- •Mechanical thrombectomy (in combination or not with intravenous thrombolysis), within the first 6 hours of the onset of symptoms, or within 24 hours in case of clinical-radiological or radiological mismatch;
- •Success of reperfusion estimated by an mTICI = 3 at the end of the procedure;
- •Availability of MRI within 3 hours of angiographic reperfusion;
- •To be able to understand the instructions given;
- •Written consent given by the patient or a trusted person;
- •To be enrolled in a social security plan;
排除标准
- •Posterieur circulation obstruction;
- •3 months follow-up impossible with the completion of the MRI;
- •Subject under a measure of legal protection
结局指标
主要结局
Description of MRI biomarkers (volume, location of the infarction and penumbra; collateral circulation; location, length of the thrombus; trans-cerebral, cortical venous changes) in patients with ischemic stroke successfully treated by thrombectomy
时间窗: Admission to hospital, 3 hours, 24 hours, 7 days and 3 months after thrombectomy
次要结局
- Kinetic evolution of MRI biomarkers (volume, location of the infarction and penumbra; collateral circulation; location, length of the thrombus; trans-cerebral, cortical venous changes) and its correlation with the functional prognosis (mRS score)(Admission to hospital, 3 hours, 24 hours, 7 days and 3 months after thrombectomy)
- Description of MRI biomarkers (volume, location of the infarction and penumbra; collateral circulation; location, length of the thrombus; trans-cerebral, cortical venous changes) and its correlation with the hemorrhagic transformation (SWAN sequence)(24 hours after thrombectomy)
- Radioclinical concordance evaluated by measuring MRI biomarkers (volume, location of the infarction and penumbra; collateral circulation; location, length of the thrombus; trans-cerebral, cortical venous changes), the mRS score and the NIHSS score(3 months after thrombectomy)
- Kinetic evolution of the NIHSS score and its correlation with the functional prognosis at 3 months evaluated by the mRS score.(Admission to hospital, 3 hours, 24 hours, 7 days and 3 months after thrombectomy)
研究者
Liang LIAO
Principal Investigator
Central Hospital, Nancy, France