Medical Imaging Screening for Posterior-circulation Ischemic Stroke
- Conditions
- Endovascular Thrombectomy
- Interventions
- Procedure: Endovascular Therapy
- Registration Number
- NCT06094569
- Lead Sponsor
- Tianjin Huanhu Hospital
- Brief Summary
Patients with ischemic stroke in the posterior circulation continue to have high rates of mortality and disability, even with aggressive treatment. We wanted to evaluate preoperative imaging to screen patients with a good prognosis from mechanical embolization. We assess the degree of ischemia by defining the pons-midbrain-medulla index (PMMI) and correlate the preoperative PMMI with the clinical prognosis of postoperative patients to verify the validity of PMMI in predicting the clinical prognosis of patients with embolization.
- Detailed Description
* The ENDOSTROKE registry (Endovascular Stroke T reatment Registry), the use of MRI before EVT was associated with significantly better clinical outcomes as compared to CT.
* The purpose of the study will sift patients with posterior circulation ischemia stroke who will get better outcome by Mechanical Thrombectomy by neuroimaging.Specifically, the following assumption will be evaluated: the modified pons-midbrain index in magnetic resonance imaging can predict the clinical outcome of patients with basilar artery thrombosis 90 days after surgery, and can guide whether patients will undergo mechanical thrombectomy later.
* Pons-midbrain-medulla index (PMMI) : We divide pons-midbrain-medulla into the left and right sides by the median line of the brainstem,so we will evaluate ischemia of these six layers which are endowed different score according to the degree of ischemia. Instead of the previous pons-midbrain index (PMI), we select the image layer that shows the largest infarct size among the six parts.Then,we add up six scores that is patient's PMMI. Scoring criteria: At the layer of displaying the maximum infarct size, 2 points are scored if the infarct size exceeds 50% of the total area, 1 point is scored if the infarct size is less than 50% of the total area, and 0 points are scored if there is no infarct.Finally, PMMI values range from 0 to 12 points.
* The investigators conduct a multicenter, prospective cohort study.Preoperative images of patients are evaluated by different groups of imaging physicians to describe the association between preoperative PMMI and clinical prognosis in patients with posterior circulation stroke and to verify its validity.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 1000
- Patient admitted from Jun. 1st 2019 to Jan. 1st 2029;
- Patients with acute ischemic stroke recently；
- Symptoms persisted at admission, and MRI (including DWI) confirmed acute ischemic vertebrobasilar artery occlusion in the posterior circulation:（single right or left intracranial branch of vertebral artery occlusion ; single basilar occlusion ; both two vertebral arterys and basilar artery）；
1.Patiens can not meet the MRI examination conditions(with absolute and relative contraindications).
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Endovascular therapy Endovascular Therapy Timely thrombectomy for acute ischemic stroke patients with large vessel occlusion by either stent retriever, thrombus aspiration, others, or combination methods.
- Primary Outcome Measures
Name Time Method Modified ranking scale (mRS) at 90 days 90 days A 0-6 scale running from perfect health without symptoms to death.
- Secondary Outcome Measures
Name Time Method Mortality within 90 days 90 days mortality of any causes.
Trial Locations
- Locations (4)
Tianjin Medical University General Hospital
🇨🇳Tianjin, Tianjin, China
Tianjin Huanhu Hospital
🇨🇳Tianjin, Tianjin, China
The Sencond Hospital of Tianjin Medical University
🇨🇳Tianjin, Tianjin, China
Beijing University Binhai Hospital
🇨🇳Tianjin, Tianjin, China