Effect of oral naloxone on constipation of patients treated by opium tincture

Phase 3

• Conditions: Drug induced constipation.; Constipation; K59.0

• Registration Number: IRCT20190207042648N3
• Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2021

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Participants that are in the opium tincture treatment in the 5 first months.
Willingness to participate in research studies.
Receiving the average dose of the opium tincture less than 10 CC in the last month.
Age between 20 - 50 years.

Exclusion Criteria

Past history of GI surgery
History of Thyroid disease
History of Diabetes
Hypercalcemia
Renal failure
Using Tricyclic antidepressant
Using Calcium Chanel blockers
Hypertension
Cardiac disease
Multi-drugs abuser
Using anticholinergic drugs
Pregnancy
Recently sever weight loss
more than 4 NVD or past history of severe labor
Parkinsonism

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Constipation score. Timepoint: At the start of treatment , one and two weeks later (end of research). Method of measurement: CONSTIPATION SCORING SYSTEM and Briston scoring.;Defecation in the three areas of abdominal, rectal and feces. Timepoint: At the start of treatment , one and two weeks later (end of research). Method of measurement: PAC-SYM questionnaire.

Secondary Outcome Measures

Name	Time	Method
Opiate withdrawal scoring. Timepoint: 24 hours after starting the treatment patients were evaluated by phone call. One and two weeks later ( end of research) were scored. Method of measurement: opiate withdrawal scale.