Medical management of compartment syndrome
Phase 4
Completed
- Conditions
- Health Condition 1: null- Patients with Isolated, Closed and Gustilo Anderson type I open proximal 2/3rd tibia fractures (Intracompartmental pressure in the leg are measured in these patients).
- Registration Number
- CTRI/2012/11/003089
- Lead Sponsor
- Christian Medical College Vellore
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
All patients presenting to emergency department with isolated acute, closed and Gustilo Anderson type I open, proximal 2/3rd tibia fracture.
Exclusion Criteria
Patients with contraindication to mannitol are excluded (heart failure, pulmonary congestion, hypotension, anuria, liver failure, intracranial bleed) .
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.The mean reduction in the compartment pressures in normal saline group and mannitol group. This will be measured 1 hr and 3 hours after giving the study and comparator drug. It will be measured by Dr. N. Jerry in all patients. <br/ ><br> <br/ ><br>2.The number of patients in whom compartment syndrome develops. This is based on the clinical criteria.Timepoint: Pressures are measured before giving the agents and 1 and 3 hours after administration.
- Secondary Outcome Measures
Name Time Method Side effect profile of mannitol drug.Timepoint: Number developing renal failure in mannitol group.