The safety and feasibility of administering Xenon-gas (anesthesia) to patients who are undergoing an off-pump (heart keeps beating on its own) bypass of the coronary artery XOPCAB stands for: Xenon in Off-Pump Coronary Artery Bypass Grafting
- Conditions
- Xenon anesthesia in cardiac surgeryTherapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
- Registration Number
- EUCTR2012-002316-12-BE
- Lead Sponsor
- niversity Hospitals of the KU Leuven
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- Not specified
- Patients with coronary artery disease scheduled for elective OPCAB-surgery
- Patients willing and able to complete the requirements of this study
- Ejection Fraction > 30%
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 20
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 20
- Lack of informed consent
- Age < 18 years
- Pregnancy
- COPD GOLD > II
- Renal dysfunction defined as serum-creatinine > 1.5 mg/dl
- Acute coronary syndrome during the last 24 hours; haemodynamic instability, requirement of inotropic support
- Single vessel grafting
- Disabling neuropsychiatric disorders (severe dementia, Alzheimer’s disease, schizophrenia, depression), history of stroke with residuals, increased intracranial pressure
- Hypersensitivity to the study medication
- Presumed uncooperativeness or legal incapacity
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method