Suspension of Mechanical Ventilation in Ureteroscopic Lithotripsy Under General Anesthesia

Not Applicable

• Conditions: Hypercapnia; Hypoxia
• Interventions: Other: PEEP

• Registration Number: NCT01835600
• Lead Sponsor: Chinese Medical Association

Brief Summary

For some upper ureteral and renal stones,ureteroscopic lithotripsy needs to be performed under general anesthesia with interrupted suspension of mechanical ventilation, which could result in hypercapnia and hypoxia. In this study, the investigators hypothesize that 10 cmH2O PEEP added to the respiratory circuit with 1 L/min 100% oxygen might extend the time of ventilation suspension but have no effect on carbon dioxide retention in blood.

Detailed Description

For some upper ureteral and renal stones,ureteroscopic lithotripsy is often perdurbed by the patient's respiratory movement either under epidural anesthesia or general anesthesia with mechanical ventilation. So intermittent suspension of mechanical ventilation under general anesthesia can ensure the surgery to be performed continuously and successfully. But this could result in hypercapnia and hypoxia. So far, there have been few studies focused on the change of the internal environment in blood as result of suspending breath. In this study, the investigators hypothesize that 10 cmH2O PEEP added to the respiratory circuit with 1 L/min 100% oxygen might extend the time of ventilation suspension but have no effect on carbon dioxide retention in blood.

Study Timeline

• Status Verified: 2013-04
• Study Start: 2013-04
• Study First Submitted: 2013-04-02
• Study First Submitted QC: 2013-04-11
• Last Update Submitted: 2013-04-11
• Study First Posted: 2013-04-19
• Last Update Posted: 2013-04-19
• Primary Completion: 2013-09
• Study Completion: 2013-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

ASA I~III general anesthesia sign the informed consent

Exclusion Criteria

ASA IV or V woman who is pregnant or plans to bear

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
with PEEP	PEEP	10 cmH2O PEEP added to the respiratory curcuit during suspension of mechanical ventilation

Primary Outcome Measures

Name	Time	Method
change in blood gas	Baseline before suspension of ventilation, 5 min after suspension, 10 min after suspension, 15 min after suspension, 5 min after re-ventilaiton, 10 min after re-ventilation	we chose different time points to mesure the changes in blood gas.

Secondary Outcome Measures

Name	Time	Method
Change in systolic blood pressure	Baseline before suspension of ventilation, 5 min after suspension, 10 min after suspension, 15 min after suspension, 5 min after re-ventilaiton, 10 min after re-ventilation	we chose different time points to mesure the changes in systolic blood pressure

Trial Locations

Locations (1)

Yi Zhou; 🇨🇳 Shanghai, Shanghai, China