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临床试验/NCT01835600
NCT01835600Unknown不适用

Suspension of Mechanical Ventilation in Ureteroscopic Lithotripsy Under General Anesthesia

Chinese Medical Association1 个研究点 分布在 1 个国家目标入组 150 人开始时间: 2013年4月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
150
试验地点
1
主要终点
change in blood gas

研究概览

简要总结

For some upper ureteral and renal stones,ureteroscopic lithotripsy needs to be performed under general anesthesia with interrupted suspension of mechanical ventilation, which could result in hypercapnia and hypoxia. In this study, the investigators hypothesize that 10 cmH2O PEEP added to the respiratory circuit with 1 L/min 100% oxygen might extend the time of ventilation suspension but have no effect on carbon dioxide retention in blood.

详细描述

For some upper ureteral and renal stones,ureteroscopic lithotripsy is often perdurbed by the patient's respiratory movement either under epidural anesthesia or general anesthesia with mechanical ventilation. So intermittent suspension of mechanical ventilation under general anesthesia can ensure the surgery to be performed continuously and successfully. But this could result in hypercapnia and hypoxia. So far, there have been few studies focused on the change of the internal environment in blood as result of suspending breath. In this study, the investigators hypothesize that 10 cmH2O PEEP added to the respiratory circuit with 1 L/min 100% oxygen might extend the time of ventilation suspension but have no effect on carbon dioxide retention in blood.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Supportive Care
盲法
Single (Participant)

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • ASA I~III general anesthesia sign the informed consent

排除标准

  • ASA IV or V woman who is pregnant or plans to bear

结局指标

主要结局

change in blood gas

时间窗: Baseline before suspension of ventilation, 5 min after suspension, 10 min after suspension, 15 min after suspension, 5 min after re-ventilaiton, 10 min after re-ventilation

we chose different time points to mesure the changes in blood gas.

次要结局

  • Change in systolic blood pressure(Baseline before suspension of ventilation, 5 min after suspension, 10 min after suspension, 15 min after suspension, 5 min after re-ventilaiton, 10 min after re-ventilation)

研究者

申办方类型
Network
责任方
Principal Investigator
主要研究者

Yi Zhou

Department of Anesthesiology , Changhai Hospital Affiliated to Second Military Medical

Chinese Medical Association

研究点 (1)

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