This is a clinical study to find the ideal combination of anesthesia inducing agents (such as propofol, etomidate or thiopentone) with dexmedetomidine as a premedicant, for attenuation of adverse hemodynamic effects produced due to laryngoscopy and tracheal intubation.
Phase 4
Completed
- Conditions
- Health Condition 1: null- Patients posted for different neurosurgical procedures
- Registration Number
- CTRI/2013/05/003606
- Lead Sponsor
- Dr Saswata Bharati
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria
ASA grade I and II patients, patients posted for various type of elective neurosurgery procedures
Exclusion Criteria
Patients with cardiac diseases, hypertension disorder, diabetes, hepatic or renal function disorder; Patients who have shown hypersensitivity to any of the drugs used in this study; Patients with CL grade 3 and 4; Patients who need intubation assistance other than using a Stylet; Patients who could not be intubated on single attempt; Patients with previous history of difficult intubation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mean blood pressure, heart rateTimepoint: Baseline before any medication <br/ ><br>At 0 minute just before laryngoscopy <br/ ><br>Then every 1 minute interval at 1 minute, 2 minute, 3 minute, 4 minute, 5 minute <br/ ><br>
- Secondary Outcome Measures
Name Time Method Mean blood pressure and heart rateTimepoint: 10 minutes after the initiation of laryngoscopy