Attenuation of hemodynamic responses to laryngoscopy and intubation in hypertensive patients: Fentanyl versus Morphine plus Lidocaine

Phase 4

Completed

• Conditions: Hypertensive patients who undergoing general anesthesia with tracheal intubation; Fentanyl; Lidocaine; Hypertensive patients; Hemodynamic response; Intubation

• Registration Number: TCTR20150607001
• Lead Sponsor: Khon Kaen Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-06-07
• Study Completion: 2021-01-29
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1.Age between 40-65 years old
2.Hypertensive patients (controlled BP < 160/90 mmHg) ASA physical status II or III
3.Elective surgery requiring general anesthesia with tracheal intubation
4.Written informed consent obtained

Exclusion Criteria

1.Cardiac surgery
2.Pregnancy
3.Obesity (body mass index > 30)
4.Expected difficult intubation
5.Nasogastric tube insertion
6.Taking beta-blockers
7.Significant medical co-morbidities (coronary artery disease, congestive heart failure, cardiac arrhythmia)
8.Contraindication/precaution to lidocaine use (eg. evidence of heart block )
9.Contraindication/precaution to morphine use (eg. asthma, COPD, chronic kidney disease stage 3 /GFR < 60 ml/min/1.73m2)
10.Allergy to study drugs

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
successfully controlled hemodynamic responses baseline, 1 minute after intubation Systolic blood pressure (SBP) and heart rate (HR)

Secondary Outcome Measures

Name	Time	Method
adverse events baseline, just before intubation, immediately after intubation, and every 1 minute unt Systolic blood pressure (SBP) and heart rate (HR)