The Role of Skeletal Muscle in the development of Insulin Resistance in Women with Polycystic Ovary Syndrome

Not Applicable

Recruiting

• Conditions: Polycystic Ovary Syndrome; Insulin Resistance; Tissue Fibrosis; Obesity; Metabolic and Endocrine - Metabolic disorders; Reproductive Health and Childbirth - Other reproductive health and childbirth disorders; Metabolic and Endocrine - Diabetes

• Registration Number: ACTRN12618000155291
• Lead Sponsor: Victoria University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-02-01
• Last Update Posted: 15 July 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 45

Inclusion Criteria

Premenopausal women aged between 18-45 with PCOS.
PCOS will be diagnosed by Rotterdam Criteria which requires two ofthe following;
1. Oligoovulation (irregular ovulation) or anovulation (lack of ovulation),
2. Clinical and/or signs of hyperandrogenism,
3. Polycystic ovaries and exclusion of other causes of hyperandrogenism.

Premenopausal women aged between 18-45 without PCOS, Control women will be defined by having no Rotterdam features.

Not using hormonal contraceptive methods (pill, implantation)
Not taking insulin sensitisers or medications which may affect endpoint data.
Not taking vitamins or natural supplements or have undergone a washout period of 1 month prior to this study.

Exclusion Criteria

Exclusion Criteria. menopause, Secondary causes of menstrual disturbance and hyperandrogenism, pregnancy, smoking, Type 1 diabetes, Type 2 diabetes mellitus, uncontrolled hypertension (>160/100mm/Hg), cardiac ischemia, established cardiovascular disease, renal impairment and malignancy, and use of medications that interfere with endpoints (e.g. contraception, metformin, anti-androgens, and progestins anti-hypertensives, and lipid-lowering agents).

Study & Design

• Study Type: Observational
• Study Design: Not specified