Acylcarnitines and Insulin Resistance

Completed

• Conditions: Insulin insensitivity; 10024450; Insulin resistance; 10018424

• Registration Number: NL-OMON35271
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

1- Lean and obese (body mass index > 20 kg/m2) subjects undergoing elective surgery
2- Age 18 - 60 years
3- Normal liver and renal function tests
4- Informed consent

Exclusion Criteria

1- Surgery for malignant or active inflammatory conditions
2- Treated diabetes
3- Any medication interfering with insulin sensitivity (steroids, beta-blockers)
4- HbA1c >8%
5- Intensive sports (> three times weekly)
6- Malignant disease
7- Infectious disease (raised erythrocyte sedimentation rate or C-reactive protein)
8- Any medical disorder of significant relevance
9- DM II in first degree family members
10- Hypertriglyceridemia or any other lipid metabolism disorder

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Acylcarnitine profiles in human plasma and muscle, liver and fatty tissue<br /><br>- The correlation between these acylcarnitine profiles and insulin sensitivity<br /><br>and resting energy expenditure in each individual patient</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>