NL-OMON48359已完成不适用
Effects of Acetate on insulin Sensitivity, CNS regulation of food intake and appetite in Humans - AISCHA study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Inclusion criteria healthy lean subject group:
- •- Healthy Caucasian male or female
- •- Age 40-65
- •- Women must be post-menopausal
- •- BMI range of 19-25 kg/m²
- •- Subjects should be able and willing to give informed consent.
- •Inclusion criteria obese metabolic syndrome subject group:
- •- Caucasian male or female with metabolic syndrome
- •- Age 40-65
- •- Women must be post-menopausal
- •- BMI range of 25-40 kg/m²
- •- At least 3 out of 5 NCEP metabolic syndrome criteria: fasting plasma glucose
- •* 5.6 mmol/L and/or HOMA-IR * 2.5, triglycerides * 1.6 mmol/L,
- •waist-circumference > 102 cm, HDL cholesterol * 1.04 mmol/L, blood pressure *
- •- Subjects should be able and willing to give informed consent.
排除标准
- •Exclusion criteria for all participants:
- •- Systemic medication use, except for paracetamol
- •- Oral or intravenous antibiotics in the past 3 months before inclusion
- •- Substance abuse
- •- Excessive weight loss (> 10% in past 3 monts)
- •- Overt diabetes mellitus type 2
- •- Malignancy (except for basal cell carcinoma)
- •- History of major heart disease
- •- History of major renal disease
- •- Pregnancy or breast feeding
- •- Implantable devices
- •- Contra-indication for MRI, such as claustrophobia or pacemaker
- •- Psychiatric illnesses: mood disorders, eating disorders, anxiety disorders,
- •schizophrenia and other psychotic disorders, dissociative disorders, somatoform
- •disorders, delirium, dementia and other cognitive disorders
- •- Simultaneous participation in other studies
- •- Inability to understand the study protocol, give informed consent or
- •participate adequately in study protocol
研究者
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