Remimazolam and desflurane for arterial oxygen partial pressure during unilateral lung ventilation : randomized controlled trial

Phase 3

• Conditions: ung tumor etc.

• Registration Number: JPRN-jRCT1051210194
• Lead Sponsor: Yamamoto Kasumi

Brief Summary

Inhaled anesthetics suppress hypoxic pulmonary vasoconstriction (HPV), whereas intravenous anesthetics such as propofol do not suppress HPV and can maintain high PaO2 during OLV. On the other hand, the effect of remimazolam on HPV is unclear. In this study, we compared the effect of remimazolam anesthesia with desflurane anesthesia on PaO2 during OLV in thoracoscopic pneumonectomy. Results showed that PaO2 during OLV was higher with maintenance of anesthesia with remimazolam than with desflurane.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-03-17
• Study Completion: 2023-05-30
• Last Update Posted: 27 May 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 31

Inclusion Criteria

1.Patients scheduled for thoracoscopic pneumonectomy with intraoperative unilateral lung ventilation
2.American Society Association physical status class 1~3
3.Patients who have sufficient judgment to understand the research content and have provided written consent

Exclusion Criteria

Patients who meet any of the following conditions are excluded:
1.Scheduled for thoracoscopic pneumonectomy with intraoperative unilateral lung ventilation for less than 2 hours
2.Undergoing bilateral lung surgery
3.History of surgery on the ventilated lung
4.History of hypersensitivity to the following
ingredients of remimazolam
desflurane or other halogenated anesthetics
remifentanil components or fentanyl compounds
rocuronium component or bromide
5.History of drug dependence
6.History of malignant hyperthermia or a history of malignant hyperthermia in their relatives
7.Acute angle-closure glaucoma
8.Myasthenia gravis or Congenital myasthenia
9.Muscular dystrophy
10.Severe aortic regurgitation
11.Shock
12.Acute intoxication
13.Received nalmefene hydrochloride within the previous week
14.Continuously receiving antihypotensive agents
15.With a chest tube inserted
16. Interstitial pneumonia
17.Pregnant or breastfeeding
18.Arterial oxygen saturation (SpO2) of less than 95% in room air, or requiring oxygen administration
19.Severe liver dysfunction (serum bilirubin level >2.5 mg / dL or PT activity level <50%)
20.BMI of less than 15 kg/m2 or more than 30 kg/m2
21.QTc is greater than or equal to 450 msec (according to Bazett's correction formula) on preoperative electrocardiogram
22.Arrhythmia more than 3 times per minute on electrocardiogram

Study & Design

• Study Type: Interventional
• Study Design: Not specified