Helium:Oxygen Noninvasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard

Phase 2

Completed

• Conditions: Bronchiolitis; Chronic Bronchitis

• Registration Number: NCT00642447
• Lead Sponsor: Baqiyatallah Medical Sciences University

Brief Summary

to assess the effect of Heliox with Noninvasive positive pressure ventilation to decrease dyspnea and improve physiologic and respiratory measures in patients with a previous exposure to Sulfur Mustard gas.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-04
• Status Verified: 2008-03
• Study First Submitted: 2008-03-19
• Study First Submitted QC: 2008-03-24
• Last Update Submitted: 2008-03-24
• Study First Posted: 2008-03-25
• Last Update Posted: 2008-03-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 23

Inclusion Criteria

• exposure to sulfur mustard
• worsening dyspnea during the last 10 days
• respiratory rate of >25/min
• arterial pH<7.35
• PaCO2 of >50 mmHg
• PaO2 of <50 mmHg

Exclusion Criteria

• recent pneumothorax (<1 month)
• severe respiratory failure or hemodynamic instability with forthcoming intubation
• FIO2 of <0.4
• impaired consciousness or absence of patient cooperation
• facial lesions precluding NIPPV

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Trial Locations

Locations (1)

BMSU; 🇮🇷 Tehran, Iran, Islamic Republic of