Microbiota and Metabolomics of Intestinal Type of Gastric Cancer in the Context of Atrophic Gastritis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Metabolomics results of lesions and atrophic gastritis.
研究概览
简要总结
Compare with the gastric cavity without cancerous transformation in atrophic gastritis, analyze the microbiota and metabolomics changes in intestinal type of gastric cancer under the background of atrophic gastritis, and explore the relevant mechanisms.
详细描述
This study adopts a prospective cohort study. The expected recruitment time for all participants is 6 months, and all cases are cases who would receive magnifying endoscopy examination. The extent of atrophy and the presence of early gastric cancer are determined under magnifying endoscopy. Cases are chose into the gastric cancer group and atrophic gastritis group in a 1:1 ratio. There are 16 cases of intestinal type of gastric cancer under the background of atrophic gastritis, and 16 cases of atrophic gastritis without gastric cancer matched according to gender, age, and degree of gastric atrophy, totaling 32 cases. Analyze the characteristics of early gastric cancer under endoscopy, investigate the changes in microbiota and metabolomics of intestinal type of gastric cancer under the background of atrophic gastritis, and explore the relevant mechanisms.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- ••Intestinal type of gastric cancer or atrophic gastritis
- •Underwent Endoscopic submucosal dissection（ESD）
排除标准
- •• have simultaneously other cancer
- •have severe systemic inflammatory disease ,serious illness such as diabetes, chronic lung diseases
结局指标
主要结局
Metabolomics results of lesions and atrophic gastritis.
时间窗: 1year
liquid chromatograph mass spectrometer metabolic profling
次要结局
- microbiomics of lesions and atrophic gastritis.(1 year)
研究者
Dong Yang
Assisted Investigator
Jilin University