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临床试验/NCT04624282
NCT04624282Unknown不适用

Metabonomics Study of Chronic Gastritis and Gastric Carcinoma

Second Affiliated Hospital, School of Medicine, Zhejiang University1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2020年11月1日最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
60
试验地点
1
主要终点
Metabonomic difference in patients with chronic gastritis and gastric carcinoma

研究概览

简要总结

The pathogenetic mechanisms of chronic gastritis and gastric carcinoma are different. Whether metabonomics play a role in the development of chronic gastritis and gastric cancer is still a question. So the investigators want to clarify this question by this subject.

详细描述

This project was an untargeted metabolomics study using liquid chromatography coupled with mass spectrometry (LC-MS) in patients with chronic gastritis and gastric carcinoma. The experimental procedures mainly include sample collection, metabolite extraction, LC-MS/MS detection, data analysis, etc.The goal of this study is to identify and (relatively) quantify as many metabolites in biological systems as possible, so as to reveal the overall metabolite information to the maximum extent. Metabolomics aims to investigate the changes of metabolites in gastric tissues in patients with chronic gastritis and gastric carcinoma, and to study the biological processes in which these metabolites participate by screening the different metabolites in the different groups, and to reveal the mechanism of life activities in which they involved in.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients with chronic superficial gastritis and chronic atrophic gastritis
  • Patients with gastric carcinoma

排除标准

  • Patients with history of surgery
  • Patients with severe heart disease,lung disease or kidney disease.

结局指标

主要结局

Metabonomic difference in patients with chronic gastritis and gastric carcinoma

时间窗: six months

1.The different levels of metabolites in gastric tissues in patients with chronic gastritis and gastric carcinoma. 2. The common change model of metabolites in gastric carcionoma compared with chronic gastritis.

次要结局

  • Association of different metabolic substances and disease results in chronic gastritis and gastric carcinoma(six months)

研究者

发起方
Second Affiliated Hospital, School of Medicine, Zhejiang University
申办方类型
Other
责任方
Principal Investigator
主要研究者

Hanyuehua

Chief physician

Second Affiliated Hospital, School of Medicine, Zhejiang University

研究点 (1)

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