Metabonomics Study of Chronic Gastritis and Gastric Carcinoma
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Metabonomic difference in patients with chronic gastritis and gastric carcinoma
研究概览
简要总结
The pathogenetic mechanisms of chronic gastritis and gastric carcinoma are different. Whether metabonomics play a role in the development of chronic gastritis and gastric cancer is still a question. So the investigators want to clarify this question by this subject.
详细描述
This project was an untargeted metabolomics study using liquid chromatography coupled with mass spectrometry (LC-MS) in patients with chronic gastritis and gastric carcinoma. The experimental procedures mainly include sample collection, metabolite extraction, LC-MS/MS detection, data analysis, etc.The goal of this study is to identify and (relatively) quantify as many metabolites in biological systems as possible, so as to reveal the overall metabolite information to the maximum extent. Metabolomics aims to investigate the changes of metabolites in gastric tissues in patients with chronic gastritis and gastric carcinoma, and to study the biological processes in which these metabolites participate by screening the different metabolites in the different groups, and to reveal the mechanism of life activities in which they involved in.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with chronic superficial gastritis and chronic atrophic gastritis
- •Patients with gastric carcinoma
排除标准
- •Patients with history of surgery
- •Patients with severe heart disease,lung disease or kidney disease.
结局指标
主要结局
Metabonomic difference in patients with chronic gastritis and gastric carcinoma
时间窗: six months
1.The different levels of metabolites in gastric tissues in patients with chronic gastritis and gastric carcinoma. 2. The common change model of metabolites in gastric carcionoma compared with chronic gastritis.
次要结局
- Association of different metabolic substances and disease results in chronic gastritis and gastric carcinoma(six months)
研究者
Hanyuehua
Chief physician
Second Affiliated Hospital, School of Medicine, Zhejiang University
