The Effect of Meal Composition on Blood Lipid Concentrations
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Blood lipid concentrations.
研究概览
简要总结
The purpose of this study is to see if a high-protein meal leads to a better postprandial (after a meal) blood lipid profile compared to a high-monounsaturated meal.
详细描述
The effect of a high-protein diet compared to a high-monounsaturated fat diet on fasting lipids is controversial (1,2), In addition, these studies did not examine the effect of a high-protein compared to a high-monounsaturated meal on postprandial lipid concentrations. Postprandial lipid responses are important to examine since they are associated with heart disease (3,4). In addition, most individuals in Western countries are in a postprandial state for majority of the day. The present study will compare the effect of a high-protein meal versus a high-monounsaturated fat meal on postprandial lipid responses.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women ages 18-65 years.
排除标准
- •Use of medications or supplements that affect lipid levels, body weight, or blood glucose,
- •following a weight loss diet,
- •being a vegan,
- •heavy alcohol use,
- •pregnancy,
- •lactation,
- •severe depression,
- •eating disorders,
- •presence of liver, kidney, gastrointestinal, adrenal, or untreated thyroid disease,
- •diabetes,
- •lactose intolerance,
- •documented mal-absorption, or
- •bowel surgery that affects absorption.
结局指标
主要结局
Blood lipid concentrations.
时间窗: At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins
次要结局
- IL-6(At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins)
- C-reactive protein(At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins)
- GLP-1(At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins)
- Glucose(At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins)
- Insulin(At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins)
- Glucagon(At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins)
- TNF-α(At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins)
- Leptin(At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins)
研究者
Meena Shah
Professor
Texas Christian University