The Effect of Meal Composition on Blood Lipids
- Conditions
- Dyslipidemia
- Registration Number
- NCT02529709
- Lead Sponsor
- Texas Christian University
- Brief Summary
The purpose of this study is to see if a high-protein meal leads to a better postprandial (after a meal) blood lipid profile compared to a high-monounsaturated meal.
- Detailed Description
The effect of a high-protein diet compared to a high-monounsaturated fat diet on fasting lipids is controversial (1,2), In addition, these studies did not examine the effect of a high-protein compared to a high-monounsaturated meal on postprandial lipid concentrations. Postprandial lipid responses are important to examine since they are associated with heart disease (3,4). In addition, most individuals in Western countries are in a postprandial state for majority of the day. The present study will compare the effect of a high-protein meal versus a high-monounsaturated fat meal on postprandial lipid responses.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 24
- Men and women ages 18-65 years.
- Use of medications or supplements that affect lipid levels, body weight, or blood glucose,
- following a weight loss diet,
- being a vegan,
- smoking,
- heavy alcohol use,
- pregnancy,
- lactation,
- severe depression,
- eating disorders,
- presence of liver, kidney, gastrointestinal, adrenal, or untreated thyroid disease,
- diabetes,
- lactose intolerance,
- documented mal-absorption, or
- bowel surgery that affects absorption.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Blood lipid concentrations. At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins
- Secondary Outcome Measures
Name Time Method IL-6 At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins C-reactive protein At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins GLP-1 At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins Glucose At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins Insulin At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins Glucagon At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins TNF-α At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins Leptin At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins
Trial Locations
- Locations (1)
Texas Christian University
🇺🇸Fort Worth, Texas, United States
Texas Christian University🇺🇸Fort Worth, Texas, United States