MEG language and memory mapping: a comparison with WADA.
Recruiting
- Conditions
- candidates for brain surgery with epilepsy and/or brain tumours.
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
1. Age between 18 and 85;
2. Has had, or will undergo, a Wada test;
Exclusion Criteria
1. Unable to undergo an MRI scan;
2. Insufficient mastery of the Dutch language;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The raw recorded MEG signals will be post-processed according to standard procedures, and artefact-free epochs will be selected by an experienced investigator. These epochs are then used to localise underlying neuronal activity using an MEG beamformer, in combination with the patient’s anatomical MRI. A lateralisation index will be computed on the basis of the reconstructed task-related neuronal power changes. In addition, a lateralisation index will be obtained from the Wada procedure by experienced neuropsychologists who are blinded to the MEG results.
- Secondary Outcome Measures
Name Time Method The lateralisation index computed on the basis of MEG and Wada, respectively, will be compared.