Cartography of Functional and Epileptic Cerebral Areas by Functional MRI and Electroencephalography in Epileptic Patients Before and After Surgery

Not Applicable

Completed

• Conditions: Epilepsy
• Interventions: Other: functional MRI

• Registration Number: NCT03102957
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

Exploring the reorganization (plasticity) of neuroanatomic networks associated with language and memory in patients with left (or dominant hemisphere) temporal lobe epilepsy using functional MRI (fMRI)

Detailed Description

The purpose of this study is to explore the reorganization of neuroanatomic networks associated with language and memory in adult patients with temporal lobe epilepsy (ELT). By using functional MRI, patients will be examined before and after surgery. Cerebral plasticity, defined in terms of intrinsic variables such as the topography of the activated regions, will be explored according to some extrinsic factors such as the age at onset of crises (before or after 5-6 years), whether or not Hippocampal sclerosis, hemispheric predominance of language (left or right).

Study Timeline

• Study Start: 2009-06-17
• Primary Completion: 2016-08-31
• Study Completion: 2016-08-31
• Status Verified: 2017-03
• Study First Submitted: 2017-03-22
• Study First Submitted QC: 2017-04-05
• Last Update Submitted: 2017-04-05
• Study First Posted: 2017-04-06
• Last Update Posted: 2017-04-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• epileptic patients
• medical exam before inclusion
• social security affiliation
• Pharmaco-resistant epilepsy

Exclusion Criteria

• MRI contraindication
• pregnant women
• breastfeeding mothers
• person under tutorship

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
epileptic patients	functional MRI	2 functional MRI (pre and post resective surgery) with memory and language tasks
Healthy volunteers	functional MRI	1 functional MRI with memory and language tasks

Primary Outcome Measures

Name	Time	Method
neuronal reorganization exploration in language and memory area thanks to functionnal MRI	one hour for each exam	fMRI exam before and after resection surgery of epileptogenic area: assess (plasticity) of neuroanatomic networks associated with language and memory - examined before and after surgery