Plasticity in brain circuits underlying interactions between pain and depressio
- Conditions
- F33Recurrent depressive disorder
- Registration Number
- DRKS00010559
- Lead Sponsor
- Zentralinstitut für Seelische Gesundheit (ZI)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 250
For all subjects:
- Sufficient german language abilities
- Ability to consent
- Residence in Mannheim or within a 50 km radius
For healthy controls
- No diagnosis of any psychiatric disorder according to ICD-10 and DSM-IV
- No family history of any psychiatric disorder according to ICD-10 and DSM-IV
For healthy first grade relatives:
- No diagnosis of any psychiatric disorder according to ICD-10 and DSM-IV
- First grade relative of patients with the diagnosis of MD according to ICD-10 or DSM-IV
For patients:
- Diagnosis of MD according to DSM-IV or V
Exclusion Criteria:
- Participant unable to content
- Acut exacerbated psychosis or psychiatric comorbidity, which needs clinical or pharmacological treatment
- Change in psychopharmacological treatment in the last 8 weeks
- Substance abuse except for nicotine
- For healthy controls and first degree relatives: psychiatric disorder according to ICD-10 or DSMIV
For the stepwise procedure additional exclusion criteria for the MRI:
- For women: pregnancy
- MR exclusion criteria (e.g. claustrophobia, pacemaker, artificial heart valves, cochlear implants, intracranial vessel clip, metal implants, brain surgery, permanent makeup, large scale tattoos on head or nape)
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary outcome:<br>Define the neural background of comorbidity between MDD and development of chronic pain assuming that altered processing pattern in MDD will facilitate chronic pain syndromes. Particularly (a) Identification of whether and how the somatosensory pattern in patients with MDD will be altered; (b) Identification of potential alterations in pain plasticity (pain facilitation and inhibition, pain-induced inhibition, intracortical restructuring of the nociceptive matrix) in patients with MDD; (c) Identification of altered neural processing (by functional and structural imaging) of pain and pain plasticity (altered pattern of fMRI, altered intracortical nociceptive matrix restructuring after hyperalgesia induction) and (d) Differentiation of state vs. trait-depen¬dency of altered pain processing in patients with MDD. <br>
- Secondary Outcome Measures
Name Time Method Secondary outcome:<br>Having characterised state and trait-related plasticity mechanisms in MDD patients with and without pain comorbidity, the next step will examine the longitudinal impact of brain plasticity on treatment response in comorbid patients in a formal treatment study. Further specify risk mecha-nisms in subjects at increased genetic (i.e. carriers of risk polymorphisms for pain and MDD, with an emphasis on genome-wide, score based methods) and environmental risk factors known to interact with genetic risk for MDD (subjects exposed to childhood adversity).<br>