Cortical inhibition and cortical plasticity in individuals with Neurofibromatosis type 1 using transcranial magnetic stimulatio
Completed
- Conditions
- Neurofibromatosis type 1Von Recklinghausen disease1002929910009841
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 62
Inclusion Criteria
- Age 18 - 55 years at inclusion
- Oral and written informed consent
- Right-handed
- NF1 patients with a clinically confirmed diagnosis
Exclusion Criteria
- Pregnancy
- Not passing the Rossi safety check-list for undergoing a TMS-measurement (Rossi et al., 2009)
- Segmental NF1
- Psychoactive agents
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- Cortical inhibition as reflected by SICI using a conditioning pulse with<br /><br>60%RMT intensity<br /><br>- Cortical plasticity as reflected by iTBS induced increase of MEP*s over the<br /><br>time course of 20 minutes after plasticity induction.</p><br>
- Secondary Outcome Measures
Name Time Method <p>- To determine the difference in motor skill learning between NF1 patients and<br /><br>unaffected controls.<br /><br>- To determine the correlation between cortical inhibition and motor<br /><br>skill learning<br /><br>- To determine the correlation between cortical plasticity and motor skill<br /><br>learning<br /><br>- To determine the correlation between cortical inhibition and cortical<br /><br>plasticity<br /><br>- To determine whether there is a difference in cortical inhibition as<br /><br>measured by the SICI (80%) TMS paradigm between adults with NF1 and unaffected<br /><br>controls<br /><br>- To determine whether there is a difference in cortical inhibition measured by<br /><br>the CSP TMS paradigm between adults with NF1 and unaffected controls. </p><br>