Cortical plasticity and Intracortical inhibition in major depressive disorder using transcranial magnetic stimulatio
Completed
- Conditions
- Major depressive disorder10027946depression
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 34
Inclusion Criteria
Unaffected controls:
Age: 18-85 years
Informed consent
Good health
Beck Depression Inventory * 9;Inpatients with MDD:
Age: 18-85 years
Informed consent
MDD confirmed diagnosis
Initial HAM-D score * 18
Being free of psychotropic drugs for 1 week
Exclusion Criteria
Pregnancy
Use of psycho-active agents
Neurological illness influencing the motor system
Not passing the Rossi safety check-list (Rossi et al., 2009)
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- Intracortical inhibition as measured with the SICI paradigm: the difference<br /><br>in MEP amplitude induced by paired pulse stimulations with a conditioning pulse<br /><br>of 80% RMT and unconditioned single TMS pulses at SI1mV.<br /><br><br /><br>- Intracortical inhibition as measured with the CSP: the duration of the CSP<br /><br>after a single supratheshold TMS pulse applied at a tonically preactivated FDI<br /><br>muscle, averaged over 20 pulses.<br /><br><br /><br>- Neuronal plasticity as measured with the iTBS: mean MEP amplitude at the FDI<br /><br>muscle before iTBS (pre-iTBS), and at 5 time points after the iTBS procedure (0<br /><br>min; 5 min; 10 min; 15 min; 20 min). The iTBS effect is determined as the mean<br /><br>MEP amplitude of the time points after iTBS relative to baseline values.</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Difference in HAM-D score at baseline and after 6 weeks of treatment as usual<br /><br>within the MDD inpatients</p><br>