Changes in cerebral activity and connectivity induced by transcranial stimulation of the dorsolateral prefrontal cortex in healthy humans
- Conditions
- transcraniale prefrontale stimulatie met gezonde proefpersonenThis study is not aimed at a certain disorder. It is a study with healthy subjects.
- Registration Number
- NL-OMON42853
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
[1] Healthy males and females,
[2] 18 years old or older,
[3] Normal (or corrected to normal) vision,
[4] Right-handed
[1] (History of) significant medical, psychiatric or neurological conditions,
[2] Metal implants in the body (e.g., pacemaker, heart valves, vascular clips, eye-implants, copper containing intra-uterine devices, non-removable piercing, cerebral implants),
[3] Any risk of having metal particles in the eyes,
[4] Tattoos containing iron oxide,
[5] (Suspected) pregnancy, or breast feeding
[6] Claustrophobia,
[7] Drug or alcohol abuse,
[8] Use of psycho-active medication,
[9] Refusal to be informed about structural brain abnormalities,
[10] Epilepsy or family history of epilepsy,
[11] Use of medication associated with increased epileptic seizure risk,
[12] Neurological problems in the past or present (including brain surgery, infarction, stroke, and the intake of medication that could increase the risk of stroke),
[13] Severe scalp skin lesions.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters are the changes in blood-oxygenation-level dependent<br /><br>(BOLD) signal induced by transcranial brain stimulation. We will measure the<br /><br>BOLD signal at rest and during the performance on two different tasks tapping<br /><br>executive functions using fMRI. </p><br>
- Secondary Outcome Measures
Name Time Method <p>In addition, we will measure cerebral blood flow (CBF) using the arterial spin<br /><br>labeling technique, and we will record MR spectroscopy data from the dorsal<br /><br>striatum. </p><br>