Change of cognitive function and brain structure in long-term breast cancer survivors
- Conditions
- Cognitive deficitsmemory and concentration problems100062911004225810009841
- Registration Number
- NL-OMON50155
- Lead Sponsor
- Antoni van Leeuwenhoek Ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
Breast cancer survivors who participated in our previous study
(NL18761.031.07).
Inclusion criteria in our previous study were:
female
treatment with adjuvant CMF chemotherapy for breast cancer between 1975 and 1995
age between 50 and 80 years
sufficient proficiency in Dutch language
Exclusion Criteria
No exclusion criteria will be applied for the current study. For our previous
study the following exclusion criteria were applied:
use of endocrine therapy
contra-indications for MRI scan
tumor relapse
metastases
second primary tumor
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1. The difference in change over time of cognitive function between breast<br /><br>cancer survivors and cancer-free individuals<br /><br>2. The difference in change over time of brain MRI measurements between breast<br /><br>cancer survivors and cancer-free individuals</p><br>
- Secondary Outcome Measures
Name Time Method <p>1. The difference in change of subjective memory complaints between breast<br /><br>cancer survivors and cancer-free individuals<br /><br>2. The predictive value of cognitive function at the first assessment for<br /><br>cognitive function at follow-up measurement among breast cancer survivors<br /><br>3. The predictive value of subjective memory complaints at the first assessment<br /><br>predict cognitive function at follow-up measurement among breast cancer<br /><br>survivors<br /><br>4. The difference in risk of dementia between breast cancer survivors and<br /><br>cancer-free individuals.<br /><br>5. The difference in change of inflammatory markers between breast cancer<br /><br>survivors and cancer-free individuals.<br /><br>6. The relation between cognitive function and inflammatory markers in breast<br /><br>cancer survivors and cancer-free individuals.</p><br>