Cognitive decline and brain structural alterations caused by metabolic dysfunction in older adults with type 2 diabetes: a prospective observational study.
- Conditions
- Older adults with type 2 diabetes mellitus.
- Registration Number
- JPRN-UMIN000042181
- Lead Sponsor
- Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology.
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 100
Not provided
Subjects who 1) are diagnosed with type 1 diabetes mellitus. 2) are diagnosed with dementia. 3) are unable to perform cognitive tests. 4) use implanted medical devices, such as pacemakers. 5) decreased cognitive function due to Parkinson's disease, apoplexy, Huntington's disease, normal pressure hydrocephalus, brain tumors, progressive supranuclear palsy, corticobasal degeneration, multiple system atrophy, aphasia, epilepsy, subdural hematoma, encephalitis/meningitis, multiple sclerosis, or head injury. 6) have any local lesion, such as cerebral infarction(s) detected by CT or MRI before enrollment, that may greatly affect cognitive function. 7) have a history of major depression, bipolar disorder, schizophrenia, or alcohol/drug abuse; have current serious or unstable disease. 8) unsuitable for treatment due to vitamin B1/B12 and/or folate deficiency, or thyroid dysfunction 9) are deemed ineligible for enrollment by the responsible researcher or co-researcher.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method