Single-pulse TMS for the assessment of corticospinal excitability and cortical motor maps
- Conditions
- Dit onderzoek heeft geen betrekking op een aandoening.not applicable
- Registration Number
- NL-OMON46542
- Lead Sponsor
- Vrije Universiteit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 25
Inclusion Criteria
Healthy participants
18-65 years old
Informed consent
Exclusion Criteria
(Family) history of epilepsy
Neurological disorder
Psychological disorder
Use of (epileptogenic) medication
Possessing a contraindication for single-pulse TMS (as determined by a TMS screening questionnaire: 'F1. Screening Questionnaire TMS safety')
Either being directly involved in the study, an employee at the research department or a family member of staff of the research department.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome measures of the study described by the amendment are the<br /><br>amplitude of the motor evoked potentials, representative of corticospinal<br /><br>excitability, and the degree of suppression of the EMG signal during an<br /><br>'ipsilateral silent period', representative for interhemispheric inhibition.<br /><br>Within a repeated measures design, differences in these measures will be tested<br /><br>across visual feedback conditions.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Relative phase of the left flexing hand with respect to the right virtual hand<br /><br>will be used as a measure of task performance.<br /><br><br /><br>Depending on the specific research questions, described in subsequent<br /><br>amendments, other secondary measures might be included. For the current<br /><br>protocol these are not applicable.</p><br>