Single-pulse transcranial magnetic stimulation for the assessment and changes of cortical motor maps in subjects with low back pain, compared to healthy subjects

Conditions: Musculoskeletale aandoeningen
non-specific Low Back Pain
recurrent a-specific low back pain

Registration Number: NL-OMON49299

Lead Sponsor: Vrije Universiteit

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 50

Inclusion Criteria

Participants experiencing episode of aspecific recurrent low back pain
Healthy participants that never experienced low back pain or experienced low
back pain more than 3 years ago
Age 18-65 years
Informed consent signed

Exclusion Criteria

(Family) history of epilepsy
Neurological disorder
Psychological disorder
Use of (epileptogenic) medication
Possessing a contraindication for single-pulse TMS (as determined by a TMS
screening questionnaire: 'Fl .
Screening Questionnaire

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Corticospinal excitability (CSE) can be assessed using single-pulse TMS across<br /><br>the primary motor cortex (M1) with EMG surface electrodes placed on the target<br /><br>muscles of the contralateral limb. Stimulation of M1, at the site of<br /><br>representation of the target muscle, will elicit motor evoked potentials (MEPs)<br /><br>in the EMG signal. The peak-to-peak amplitude of a MEP is considered to<br /><br>quantify CSE, with the measured MEPs the CoG is calculated,, which is the main<br /><br>outcome measure of this study. A stimulation intensity of 130% RMT will be<br /><br>employed to obtain this outcome measure. When RMT is not enough to evoke a MEP,<br /><br>RMT will be aksed by letting the subject lean to the back. CSR of the lower<br /><br>back and abdominal muscles will be determined by measuring the cross sectional<br /><br>area of the hotspot leading to MEP*s in the lower back and abdominal muscles. </p><br>

Secondary Outcome Measures