Transcranial Magnetic Stimulation in the Treatment of Addiction. Repetitive transcranial magnetic stimulation (rTMS) in alcohol dependent patients: a mechanistic study.
- Conditions
- afhankelijkheid van alcoholalcohol addiction
- Registration Number
- NL-OMON40252
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 30
•Right-handed males between 23-65 years of age
•A primary diagnose of alcohol dependence (meeting the DSM-IV-TR criteria 303.90/ICD-10 F10.2)
•Written consent for participation of the study.
•MATE outcome <4 (as extracted from part 4 MATE at enrollment phase) MATE= Dutch screening instrument on (among others) addiction severity
•Presence of a current or past relevant somatic or neurological disorder
•Meeting the DSM-IV-TR criteria for a current bipolar disorder, schizophrenia, anxiety disorder or moderate to severe depressive disorder. These disorders would be a possible great confounder. Measured with the MINI-plus.
•Meeting the DSM-IV-TR criteria for current (in the past 2 weeks) dependence of substances other than alcohol, nicotine or caffeine. Information present in MATE.
•Participant-bound factors that may endanger participants or may jeopardize study adherence, because of failure to understand and/or comply with instructions (e.g. current, disruptive symptoms such as psychotic symptoms or severe cognitive impairment)
•Contra-indications resulting from the use of rTMS:;*Epilepsy, convulsion or seizure
*Serious head trauma or brain surgery
*Large or ferromagnetic metal parts in the head (except for a dental wire)
*Implanted cardiac pacemaker or neurostimulator
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The change from baseline on the amplitude of the LPP at 8 weeks. Time Frame: 8<br /><br>weeks after start of treatment.<br /><br>To investigate the effect of 20 sessions of rTMS on the change in amplitude of<br /><br>the Late Positive Potentials (LPP) (P300 and Slow Potential (SP)) as measured<br /><br>with EEG at 8 weeks after start of treatment (baseline measurement).</p><br>
- Secondary Outcome Measures
Name Time Method