The effects of Transcranial Magnetic Stimulation on freezing in Parkinson's Disease patients with Freezing of Gait

Completed

• Conditions: freezing of gait; Parkinson's Disease; 10028037

• Registration Number: NL-OMON35602
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

- Idiopathic Parkinson's Disease patients diagnosed according to the UK Brain Bank criteria.
- Hoehn and Yahr stage 2 or 3.
- Presence of freezing of gait.

Exclusion Criteria

- Presence of neurological disease other than Parkinson's Disease.
- Presence of deep brain stimulator.
- MMSE score under 24
- Contra indications for administrating TMS

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome for this study is the total time a patient freezes during<br /><br>the gait and upper limb task. This outcome will be rated by a blinded<br /><br>examinator who rates the videos of the different tasks off-line.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. The stride length (amplitude) and velocity in the gait task.<br /><br>2. The amplitude and velocity of the flexion-extension movement of the index<br /><br>fingers in the upper limb task.<br /><br>3. The average duration and the frequency of freezing in the gait and the upper<br /><br>limb task.<br /><br>4. MEP amplitude before and after TBS stimulation.<br /><br>5. The performance on the pegboard test.</p><br>