Applying transcranial magnetic stimulation concurrently with functional MRI: investigating disturbed transcallosal signalling in patients

Completed

• Conditions: auditory verbal hallucinations; schizophrenia; 10039628

• Registration Number: NL-OMON36283
• Lead Sponsor: Divisie Hersenen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 70

Inclusion Criteria

Healthy volunteers:
- for experiment 1: between age 18-40yr.
- for experiment 2: matched with available patient group with respect to age (18-65yr), gender and education;Patients:
- between age 18-65yr
- diagnosed with schizophrenia according to DSM IV will be included.
- able to lie in an MRI scanner and prevent head movements for a short period of time (about 15 minutes)

Exclusion Criteria

The following list of exclusion criteria is for both controls and patients, unless noted.
- non-removable metal objects in head/body
- pregnancy
- history of closed- or open head injury
- history of psychiatric illness (healthy controls only)
- history of neurological illness or endocrinological dysfunction
- history of epilepsy
- occurrence of epilepsy in 1st degree family
- use of medication other than anticonceptive or paracetamol (healthy controls only)
- drug or alcohol abuse over a period of six months prior to the experiment
- intake of alcohol, caffeine or nicotine containing products within 4 hrs prior to the scanning sessions.
- claustrofobia

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters for experiment 1 are functional brain networks evoked<br /><br>with TMS. Such a network consists of maps of induced percent signal change in<br /><br>BOLD MR images over the entire brain. In experiment 2 the main outcome is the<br /><br>difference in percent signal change between patients and controls along<br /><br>connections in the language network. See also chapter 5 of the protocol text.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>