Responsiveness to transcranial magnetic stimulation for treatment of motor deficits after resection of supratentorial brain tumors

Phase 2

Recruiting

• Conditions: C71; Malignant neoplasm of brain

• Registration Number: DRKS00033513
• Lead Sponsor: Charité - Universitätsmedizin Berlin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-05-17
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

Patients after resection of a supratentorial brain tumor
- Deterioration of motor status immediately postoperatively compared to preoperative status
- Age = 18 years
- Patients whose physical and mental condition allows them to give full and comprehensive informed consent
- Written declaration of consent

Exclusion Criteria

- Patients with contraindications for MRI imaging
- Patients with contraindications for a TMS examination
- >1 generalized seizure per week
- Pregnancy
- Age < 18 years
- Lack of consent to participate in the study

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Responsiveness as the proportion of treatment successes of patients based on the difference ? of the BMRC value of the treated extremity one month postoperatively compared to the baseline BMRC value before the start of rTMS therapy (success if ? = 1).

Secondary Outcome Measures

Name	Time	Method
- National Institutes of Health Stroke Scale (NIHSS)<br>- Finger or toe tapping score depending on the affected extremity<br>- Karnofsky Performance Status Scale (KPS)<br>- Quality of life (EORTC QLQ BN20)<br>- Characteristics of the tumor (location, volume, histology)<br>- Characteristics of the operation (anesthesia, extent of resection, resection of motor eloquent areas, presence of ischemia)<br>- TMS parameters (resting motor threshold, measurability of MEPs)