Transcranial Magnetic Stimulation (TMS) treatment study in auditory verbal hallucinations
Completed
- Conditions
- Schizophrenia or schizoaffective disorder, medication resistant auditory hallucinationsMental and Behavioural DisordersSchizophrenia
- Registration Number
- ISRCTN61109178
- Lead Sponsor
- Swiss National Fund (Switzerland)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 45
Inclusion Criteria
1. Diagnosis of schizophrenia or schizoaffective disorder according to ICD-10
2. Medication-resistant auditory verbal hallucinations
3. 18?65-years of age, and right-handed
4. Therapy refractoriness is defined as non response to at least 2 antipsychotic treatments in common dosages, each administered for at least 8 weeks
Exclusion Criteria
1. History of epileptic seizures
2. Signs of elevated neuronal activity by electroencephalography (EEG)
3. Magnetic resonance (MR) contraindications, and
4. Medical disorders other than schizophrenia or schizoaffective disorder
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Psychopathology rates:<br>1.1. Positive and negative symtpom scale<br>1.2. Psychotic Symptom Rating Scales (PSYRATS)<br>1.3. Auditory hallucination rating scale<br>2. Cerebral blood flow as measured by magnetic resonance arterial spin labeling
- Secondary Outcome Measures
Name Time Method 1. Comparison of conventionally used 10-20 EEG coil placement approach with a frameless steretactic neuronavigation system to functionally defined (fMRI) target area<br>2. TMS effects on electroencephalography measures<br>3. Assessment of side effects