rTMS-induced Cumulative Pattern of sBDNF in Chronic Schizophrenia

Not Applicable

Completed

• Conditions: Mental and behavioral disorders

• Registration Number: KCT0000190
• Lead Sponsor: Maeumsarang Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 11 March 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1. Patients with schizophrenia satisfying the criteria according to DMS-IV-TR
2. Patients in chronic and stable phase, and on stable medication
3. duration of illness: over 10 years
4. no dosage change within at least 2 weeks
5. age range from 25 to 60 years old
6. patients able to provide written consents with voluntary participation

Exclusion Criteria

1. left-handedness or both-handedness
2. patients taking anticonvulsants
3. patients taking bezodiazepine over 3mg lorazepam equivalents
4. History of mental retardation or severe state of regression
5. History of epilepsy or neurological disease, or head trauma
6. alcohol or substance use disorder(except nicotine)
7. severe medical or surgical problems
8. cardiac pacemaker or intracranial clips or metallic materials
9. pregnancy in women

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
degree in change from baseline of serum BDNF;pattern(slope) in change from baseline of serum BDNF;elasticity of change of serum BDNF in each interval

Secondary Outcome Measures

Name	Time	Method
Clinical Global Impression-Severity;Clinical Global Impression-Change;PANSS(positive and negative symptom scale)