Repetitive transcranial magnetic stimulation (rTMS) for the treatment of chronic tinnitus

Completed

Conditions: Chronic tinnitus
Nervous System Diseases
Tinnitus

Registration Number: ISRCTN89848288

Lead Sponsor: niversity of Regensburg (Germany)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 138

Inclusion Criteria

1. Male or female in- and out-patients, age 18-70
2. Diagnosis of chronic tinnitus
3. Patient has a score of greater than or equal to 38 on the Tinnitus Handicap Inventory
4. Tinnitus duration of more than 6 months
5. Age-adjusted normal sensorineuronal hearing determined by an audiogram within the last 4 weeks, i.e. no more than 5 dB below the 10% percentile (DIN EN ISO 7029) of the appropriate age and gender group in all measured standard frequencies. Furthermore, no conductive hearing loss of more than 15 dB in neither of the measured standard frequencies
6. Patient naïve to rTMS-treatment

Exclusion Criteria

1. Objective tinnitus
2. Other forms of tinnitus treatment at the same time
3. Clinically relevant psychiatric comorbidity as judged by an experienced psychiatrist
4. Concomitant treatment with psychotropic drugs
5. History of or evidence of significant brain malformation or neoplasm, head injury, cerebral vascular events, neurodegenerative disorder affecting the brain or prior brain surgery
6. Severe unstable somatic comorbidity
7. Cardiac pace makers, other electronic implants, intracranial metallic particles
8. History of seizures or epileptiform activity
9. Pregnancy and lactation
10. Women in child bearing age without contraception
11. Patients who cannot communicate reliably with the investigator or who are not likely to cope with the requirements of the trial
12. Patient unwilling or unable to give written informed consent
13. Participation in a clinical trial within the last 30 days before start of this clinical trial or similar participation in another clinical trial