Optimised Transcranial Magnetic Stimulation (TMS) for Obsessive Compulsive Disorder (OCD)

Not Applicable

• Conditions: Obsessive Compulsive Disorder; Mental Health - Other mental health disorders; Mental Health - Anxiety

• Registration Number: ACTRN12619000008123
• Lead Sponsor: Monash University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-01-08
• Study Completion: 2022-06-17
• Last Update Posted: 9 August 2022

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 49

Inclusion Criteria

1.Age of 18 to 65 years inclusive?
2.Does the patient have a primary diagnosis of Obsessive-Compulsive Disorder (OCD) according to the DSM-V criteria?
3.Does the patient currently score between 17-31 (ie. Moderate to severe) on the Yale and Brown Obsessive Compulsive Scale (Y-BOCS)?
** Please Note: completion of the Y-BOCS is not a required prerequisite for the Clinical Trial, but rather a gauge on the severity of symptoms that we require for participation. We will assess the patient on this measure as part of the clinical assessments. If you have not completed the Y-BOCS with the patient but they have moderate to severe OCD symptoms, please circle N/A.
4.Has the patient had a diagnosis of OCD for a period greater than 12 months?
5.Does the patient have the capacity to give informed consent to participate in the clinical trial?
6.Will the patient be able to attend the Epworth Centre for Innovation in Mental Health (Mon-Fri) for 3 weeks?

Exclusion Criteria

1.Does the patient have any contraindication to having a magnetic resonance imaging (MRI)?
2.Does the patient have any contraindication to having transcranial magnetic stimulation (TMS)?
3.Has the patient ever been diagnosed with a psychotic disorder?
4.Has the patient ever been diagnosed with Bipolar I or II?
5.Does the patient have any medical condition that would interfere with treatment?
6.Has the patient’s pharmaceutical treatment changed in the past three months?
7.Does the patient have Tourette’s syndrome?
8.Has the patient ever suffered from a substance abuse disorder or alcohol/drug misuse?
9.Is the participant pregnant or planning to become pregnant during the duration of the trial?

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference in Yale and Brown Obsessive Compulsive Scale (Y-BOCS) score<br>[Baseline and end of treatment];Differences in fronto-striatal functional connectivity as assessed by fMRI [Baseline and end of treatment]

Secondary Outcome Measures

Name	Time	Method
Belief domains of the Obsessive Beliefs Questionnaire-44 (OBQ-44)[Baseline and end of treatment];The Obsessive–Compulsive Inventory, short version (OCI-R)<br>[Baseline and end of treatment];Montgomery Asberg Depression Rating Scale (MADRS)<br>[Baseline and Endpoint];Hamilton Anxiety Rating Scale (HAM-A)[Baseline and End of treatment];Hospital Anxiety and Depression Scale (HADS)[Baseline and end of treatment]