A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
- Conditions
- Colorectal Neoplasms
- Interventions
- Registration Number
- NCT05253651
- Lead Sponsor
- Seagen, a wholly owned subsidiary of Pfizer
- Brief Summary
This study is being done to find out if tucatinib with other cancer drugs works better than standard of care to treat participants with HER2 positive colorectal cancer. This study will also determine what side effects happen when participants take this combination of drugs. A side effect is anything a drug does to the body besides treating your disease.
Participants in this study have colorectal cancer that has spread through the body (metastatic) and/or cannot be removed with surgery (unresectable).
Participants will be assigned randomly to the tucatinib group or standard of care group. The tucatinib group will get tucatinib, trastuzumab, and mFOLFOX6. The standard of care group will get either:
* mFOLFOX6 alone,
* mFOLFOX6 with bevacizumab, or
* mFOLFOX6 with cetuximab mFOLFOX6 is a combination of multiple drugs. All of the drugs given in this study are used to treat this type of cancer.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 400
-
Histologically and/or cytologically confirmed adenocarcinoma of the colon or rectum which is locally advanced unresectable or metastatic
-
Able to provide the most recently available formalin-fixed paraffin-embedded (FFPE) tumor tissue blocks (or freshly sectioned slides) obtained prior to treatment initiation to a central laboratory
- If archival tissue is not available, a newly-obtained baseline biopsy of an accessible tumor lesion is required within 35 days prior to start of study treatment
-
HER2+ disease as determined by a tissue based assay performed at a central laboratory.
-
Participant has rat sarcoma viral oncogene homolog wild-type (RAS WT) disease as determined by local or central testing. For central RAS analysis, tissue sample must be analyzed within 1 year of biopsy date.
-
Radiographically measurable disease per RECIST v1.1 with:
- At least one site of disease that is measurable and that has not been previously irradiated, or
- If the participant has had previous radiation to the target lesion(s), there must be evidence of progression since the radiation
-
Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
-
CNS Inclusion - based on contrast brain magnetic resonance imaging, participants may have any of the following:
- No evidence of brain metastases
- Previously treated brain metastases which are asymptomatic
-
Prior systemic anticancer therapy for colorectal cancer (CRC) in the locally advanced unresectable or metastatic setting; note that participants may have received a maximum of 2 doses of mFOLFOX6 in the locally advanced/unresectable or metastatic setting prior to randomization.
- Note: May have received chemotherapy for CRC in the adjuvant setting if it was completed >6 months prior to enrollment
-
Radiation therapy within 14 days prior to enrollment (or within 7 days in the setting of stereotactic radiosurgery)
-
Previous treatment with anti-HER2 therapy
-
Ongoing Grade 3 or higher neuropathy
-
Active or untreated gastrointestinal (GI) perforation at the time of screening.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Tucatinib Arm tucatinib Tucatinib + trastuzumab + mFOLFOX6 Tucatinib Arm trastuzumab Tucatinib + trastuzumab + mFOLFOX6 Tucatinib Arm oxaliplatin Tucatinib + trastuzumab + mFOLFOX6 Tucatinib Arm leucovorin Tucatinib + trastuzumab + mFOLFOX6 Tucatinib Arm levoleucovorin Tucatinib + trastuzumab + mFOLFOX6 Tucatinib Arm fluorouracil Tucatinib + trastuzumab + mFOLFOX6 Standard of Care Arm bevacizumab Either (1) mFOLFOX6, (2) mFOLFOX6 and bevacizumab, or (3) mFOLFOX6 and cetuximab Standard of Care Arm cetuximab Either (1) mFOLFOX6, (2) mFOLFOX6 and bevacizumab, or (3) mFOLFOX6 and cetuximab Standard of Care Arm oxaliplatin Either (1) mFOLFOX6, (2) mFOLFOX6 and bevacizumab, or (3) mFOLFOX6 and cetuximab Standard of Care Arm leucovorin Either (1) mFOLFOX6, (2) mFOLFOX6 and bevacizumab, or (3) mFOLFOX6 and cetuximab Standard of Care Arm levoleucovorin Either (1) mFOLFOX6, (2) mFOLFOX6 and bevacizumab, or (3) mFOLFOX6 and cetuximab Standard of Care Arm fluorouracil Either (1) mFOLFOX6, (2) mFOLFOX6 and bevacizumab, or (3) mFOLFOX6 and cetuximab
- Primary Outcome Measures
Name Time Method Progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1) by Blinded Independent Central Review (BICR) Up to approximately 3 years The time from the date of randomization to the BICR assessment of disease progression according to RECIST v1.1 or death from any cause
- Secondary Outcome Measures
Name Time Method Duration of response (DOR) per RECIST v1.1 by BICR Up to approximately 3 years The time from first documentation of objective response (CR or PR that is subsequently confirmed) to the first documentation of disease progression per RECIST v1.1 or death from any cause
DOR per RECIST v1.1 by investigator assessment Up to approximately 3 years The time from first documentation of objective response (CR or PR that is subsequently confirmed) to the first documentation of disease progression per RECIST v1.1 or death from any cause
Time to second progression or death (PFS2) Up to approximately 3 years The time from randomization to disease progression on the next-line of therapy, or death from any cause
Incidence of adverse events (AEs) Through 30 days after the last study treatment; approximately 1 year Any untoward medical occurrence in a clinical investigational participant administered a medicinal product and which does not necessarily have a causal relationship with this treatment.
Trough concentration (Ctrough) Approximately 4 months PK parameter
Overall survival (OS) Up to approximately 6 years The time from randomization to death from any cause
Confirmed objective response rate (cORR) per RECIST v1.1 by BICR Up to approximately 3 years The proportion of participants with confirmed complete response (CR) or partial response (PR) according to RECIST v1.1, as assessed by BICR
PFS per RECIST v1.1 by investigator assessment Up to approximately 3 years The time from the date of randomization to the investigator assessment of disease progression according to RECIST v1.1 or death from any cause
cORR per RECIST v1.1 by investigator assessment Up to approximately 3 years The proportion of participants with confirmed CR or PR according to RECIST v1.1, as assessed by investigators
Incidence of dose alterations Through 30 days after the last study treatment; approximately 1 year Change from baseline in European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQC30) score Through 30-37 days after the last study treatment; approximately 1 year Change from baseline in European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) scores. Scale scores range from 0-100. For functioning and global health status/quality of life (QoL) scales, higher scores indicate better functioning or global health status/quality of life (QoL). For symptom scales, higher scores indicate greater symptom burden.
Time to meaningful change in EORTC QLQ30 score Through 30-37 days after the last study treatment; approximately 1 year The time from baseline to the first onset of a ≥10-point changes in European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) scores. Scale scores range from 0-100.
For functioning and global health status/QoL scales, higher scores indicate better functioning or global health status/QoL. For symptom scales, higher scores indicate greater symptom burden.
Trial Locations
- Locations (347)
Pacific Cancer Medical Center Inc.
🇺🇸Anaheim, California, United States
Palo Verde Hematology Oncology
🇺🇸Glendale, Arizona, United States
Mayo Clinic Building - Phoenix
🇺🇸Phoenix, Arizona, United States
Mayo Clinic Hospital
🇺🇸Phoenix, Arizona, United States
Mayo Clinic
🇺🇸Rochester, Minnesota, United States
Kaiser Permanente Anaheim Kraemer Medical Offices
🇺🇸Anaheim, California, United States
Kaiser Permanente Baldwin Park Medical Center
🇺🇸Baldwin Park, California, United States
Kaiser Permanente Bellflower Medical Offices
🇺🇸Bellflower, California, United States
Kaiser Permanente Fontana Medical Center
🇺🇸Fontana, California, United States
Los Angeles Hematology Oncology Medical Group
🇺🇸Van Nuys, California, United States
Kaiser Permanente South Bay Medical center
🇺🇸Harbor City, California, United States
Kaiser Permanente Alton/Sand Canyon Medical Offices
🇺🇸Irvine, California, United States
USC Norris Koreatown - Medical Oncology
🇺🇸Los Angeles, California, United States
Kaiser Permanente Los Angeles Medical Offices
🇺🇸Los Angeles, California, United States
Keck Hospital of USC
🇺🇸Los Angeles, California, United States
USC/Norris Comprehensive Cancer Center / Investigational Drug Services
🇺🇸Los Angeles, California, United States
USC/Norris Comprehensive Cancer Center
🇺🇸Los Angeles, California, United States
Kaiser Permanente West Los Angeles Medical Center
🇺🇸Los Angeles, California, United States
USC Norris Oncology/Hematology - Newport Beach
🇺🇸Newport Beach, California, United States
Kaiser Permanente Ontario Medical Center
🇺🇸Ontario, California, United States
Kaiser Permanente Panorama City Medical Center
🇺🇸Panorama City, California, United States
Keck Medical Center of USC Pasadena
🇺🇸Pasadena, California, United States
Kaiser Permanente Riverside Medical Center
🇺🇸Riverside, California, United States
Kaiser Permanente San Diego Mission Road (Regulatory and Lab Supplies)
🇺🇸San Diego, California, United States
Kaiser Permanente Zion Medical Center
🇺🇸San Diego, California, United States
Kaiser Permanente San Marcos Medical Offices
🇺🇸San Marcos, California, United States
Kaiser Permanente Woodland Hills Medical Center
🇺🇸Woodland Hills, California, United States
Rocky Mountain Cancer Centers, LLP
🇺🇸Thornton, Colorado, United States
Mount Sinai Medical Center Aventura ER
🇺🇸Aventura, Florida, United States
Mount Sinai Comprehensive Cancer Center
🇺🇸Miami Beach, Florida, United States
Mount Sinai Medical Center
🇺🇸Miami Beach, Florida, United States
Grady Health System
🇺🇸Atlanta, Georgia, United States
Grady Memorial Hospital Investigational Drug Service
🇺🇸Atlanta, Georgia, United States
Emory University Hospital Midtown
🇺🇸Atlanta, Georgia, United States
Emory University Hospital
🇺🇸Atlanta, Georgia, United States
Investigational Drug Service
🇺🇸Atlanta, Georgia, United States
Winship Cancer Institute
🇺🇸Atlanta, Georgia, United States
Alliance for Multispecialty Research LLC.
🇺🇸Merriam, Kansas, United States
Baptist Health Lexington
🇺🇸Lexington, Kentucky, United States
Norton Cancer Institute - Downtown
🇺🇸Louisville, Kentucky, United States
Norton Cancer Institute, Downtown
🇺🇸Louisville, Kentucky, United States
Norton Hospital
🇺🇸Louisville, Kentucky, United States
Norton Audubon Hospital
🇺🇸Louisville, Kentucky, United States
Norton Cancer Institute, Audubon Hospital Campus
🇺🇸Louisville, Kentucky, United States
Norton Brownsboro Hospital
🇺🇸Louisville, Kentucky, United States
Norton Cancer Institute, Brownsboro Hospital Campus
🇺🇸Louisville, Kentucky, United States
Minnesota Oncology Hematology, PA
🇺🇸Minneapolis, Minnesota, United States
Allina Health Cancer institute
🇺🇸Coon Rapids, Minnesota, United States
M Health Fairview Cancer Clinic-Edina
🇺🇸Edina, Minnesota, United States
M Health Fairview St. John's Hospital
🇺🇸Maplewood, Minnesota, United States
Allina Health Cancer Institute (Virginia Piper Cancer Institute)
🇺🇸Minneapolis, Minnesota, United States
Hennepin County Medical Center
🇺🇸Minneapolis, Minnesota, United States
North Memorial Health Cancer Center
🇺🇸Robbinsdale, Minnesota, United States
Mayo Clinic Cancer Center Outpatient Pharmacy
🇺🇸Rochester, Minnesota, United States
Metro Minnesota Community Oncology Research Consortium
🇺🇸Saint Louis Park, Minnesota, United States
Park Nicollet Frauenshuh Cancer Center
🇺🇸Saint Louis Park, Minnesota, United States
Regulatory Location: MMCORC
🇺🇸Saint Louis Park, Minnesota, United States
Regions Hospital
🇺🇸Saint Paul, Minnesota, United States
Minnesota Oncology Hematology, PA St. Paul Cancer Center
🇺🇸Saint Paul, Minnesota, United States
Minnesota Oncology Hematology, PA Cornerstone Medical Specialty Center
🇺🇸Woodbury, Minnesota, United States
MSK Basking Ridge
🇺🇸Basking Ridge, New Jersey, United States
MSK Monmouth
🇺🇸Middletown, New Jersey, United States
MSK Bergen
🇺🇸Montvale, New Jersey, United States
MSK Commack
🇺🇸Commack, New York, United States
MSK Westchester
🇺🇸Harrison, New York, United States
Rockefeller Outpatient Pavilion (53rd Street)
🇺🇸New York, New York, United States
Memorial Solan Kettering Cancer Center- Main Campus
🇺🇸New York, New York, United States
MSK Nassau
🇺🇸Uniondale, New York, United States
Duke University Hospital
🇺🇸Durham, North Carolina, United States
Duke University Medical Center, Duke Cancer Center
🇺🇸Durham, North Carolina, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
FirstHealth Cancer Center
🇺🇸Pinehurst, North Carolina, United States
FirstHealth Moore Regional Hospital
🇺🇸Pinehurst, North Carolina, United States
Gabrail Cancer Center Research
🇺🇸Canton, Ohio, United States
Providence Cancer Institute Newberg Clinic
🇺🇸Newberg, Oregon, United States
Providence Cancer Institute Willamette Falls Clinic
🇺🇸Oregon City, Oregon, United States
Northwest Cancer Specialists, P.C.
🇺🇸Vancouver, Washington, United States
Providence Cancer Institute Franz Clinic
🇺🇸Portland, Oregon, United States
Providence Portland Medical Center
🇺🇸Portland, Oregon, United States
Providence Oncology and Hematology Care Clinic - Westside
🇺🇸Portland, Oregon, United States
Providence St. Vincent Medical Center- Investigational Drug Services
🇺🇸Portland, Oregon, United States
Providence St. Vincent Medical Center
🇺🇸Portland, Oregon, United States
Avera Cancer Institute
🇺🇸Sioux Falls, South Dakota, United States
Henry-Joyce Cancer Clinic
🇺🇸Nashville, Tennessee, United States
The University of Texas MD Anderson Cancer Center
🇺🇸Houston, Texas, United States
University of Texas MD Anderson Cancer Center
🇺🇸Houston, Texas, United States
US Oncology Investigational Product Center (IPC)
🇺🇸Irving, Texas, United States
US Oncology Investigational Products Center (IPC)
🇺🇸Irving, Texas, United States
US Oncology Investigational Products Center(IPC)
🇺🇸Irving, Texas, United States
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care
🇺🇸Salem, Virginia, United States
Oncology & Hematology Associates of Southwest Virginia
🇺🇸Wytheville, Virginia, United States
Oncology & Hematology Associates of Southwest Virginia Inc dba Blue Ridge Cancer Care
🇺🇸Roanoke, Virginia, United States
Providence Regional Cancer Partnership
🇺🇸Everett, Washington, United States
Providence Regional Medical Center Everett
🇺🇸Everett, Washington, United States
Centro de Investigacion Pergamino SA
🇦🇷Pergamino, Buenos Aires, Argentina
Instituto Medico de la Fundacion Estudios Clinicos
🇦🇷Rosario, Santa FE, Argentina
Hospital Britanico de Buenos Aires
🇦🇷Caba, Argentina
Instituto Medico Especializado Alexander Fleming
🇦🇷Ciudad Autónoma de Buenos Aires, Argentina
IONC Instituto Oncologico de Cordoba Fundacion Richardet Longo
🇦🇷Cordoba, Argentina
CEMAIC - Centro Medico Privado
🇦🇷Cordoba, Argentina
Townsville Hospital and Health Service
🇦🇺Townsville, Queensland, Australia
St Vincent's Hospital
🇦🇺Fitzroy, Victoria, Australia
Alfred Health
🇦🇺Melbourne, Victoria, Australia
Klinikum Wels-Grieskirchen GmbH Austria
🇦🇹Wels, Austria
Landesapotheke Salzburg
🇦🇹Salzburg, Austria
Uniklinikum Salzburg, Landeskrankenhaus
🇦🇹Salzburg, Austria
Landesklinikum Wiener Neustadt
🇦🇹Wiener Neustadt, Austria
Institut Jules Bordet
🇧🇪Anderlecht, Belgium
Cliniques Universitaires Saint-Luc
🇧🇪Brussels, Belgium
UZA
🇧🇪Edegem, Belgium
CHU HELORA - Hopital de Jolimont
🇧🇪Haine-Saint-Paul, Belgium
Centre Hospitalier Chretien - Clinique MontLegia
🇧🇪Liège, Belgium
Maag-,Darm- en Leverziekten AZ Turnhout
🇧🇪Turnhout, Belgium
Oncologisch Dagziekenhuis AZ Turnhout Campus Sint-Elisabeth
🇧🇪Turnhout, Belgium
CIONC-Centro Integrado de Oncologia de Curitiba
🇧🇷Curitiba, Parana, Brazil
Centro Integrado de Pesquisa em Oncologia CIPO-GHC / Hospital Nossa Senhora da Conceicao
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Institute de Educacao, Pesquisa e Gestao em Saude - Instituto COI
🇧🇷Rio de Janeiro, RJ, Brazil
Hospital de Cancer de Barretos/Fundacao Pio XII
🇧🇷Barretos, SAO Paulo, Brazil
Centro de Pesquisas Clinicas da Fundação Doutor Amaral Carvalho
🇧🇷Jau, SAO Paulo, Brazil
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia.
🇧🇷Santo Andre, SAO Paulo, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto
🇧🇷Sao Jose do Rio Preto, SP, Brazil
ICESP - Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira.
🇧🇷Sao Paulo, Brazil
The Ottawa Hospital Cancer Centre
🇨🇦Ottawa, Ontario, Canada
Hopital Saint-Antoine
🇫🇷Paris, France
Sunnybrook Research Institute
🇨🇦Toronto, Ontario, Canada
Hopital Europeen Georges Pompidou
🇫🇷Paris, France
Mount Sinai Hospital
🇨🇦Toronto, Ontario, Canada
Jewish General Hospital
🇨🇦Montreal, Quebec, Canada
Saskatoon Cancer Centre
🇨🇦Saskatoon, Saskatchewan, Canada
Oncocentro Apys
🇨🇱Viña del Mar, Valparaíso, Chile
Biocenter
🇨🇱Concepcion, Chile
Centro de estudios clinicos SAGA
🇨🇱Santiago, Chile
Fujian Medical University Union Hospital
🇨🇳Fuzhou, Fujian, China
The 900th Hospital of The Chinese People's Liberation Army Joint Logistics Support Force
🇨🇳Fuzhou, Fujian, China
The First hospital of LanZhou university
🇨🇳Lanzhou, Gansu, China
The Sixth Affiliated hospital, Sun Yat-sen University
🇨🇳Guangzhou, Guangdong, China
Meizhou People's Hospital - Guangdong Province
🇨🇳Meizhou, Guangdong, China
Meizhou People's hospital
🇨🇳Meizhou, Guangdong, China
The Second Affiliated Hospital of Hainan Medical University
🇨🇳Haikou, Hainan, China
Hainan General Hospital
🇨🇳Haikou, Hainan, China
Affiliated Hospital of Chengde Medical University
🇨🇳Chengde, Hebei, China
Tangshan People's Hospital
🇨🇳Tangshan, Hebei, China
Harbin Medical University Cancer Hospital
🇨🇳Harbin, Heilongjiang, China
Nanyang Second General Hospital
🇨🇳Nanyang, Henan, China
CHU Bordeaux Hopital Haut Leveque
🇫🇷Pessac, France
Henan Provincial People's Hospital
🇨🇳Zhengzhou, Henan, China
Hubei Cancer Hospital
🇨🇳Wuhan, Hubei, China
The Second Xiangya Hospital of Central South University
🇨🇳Changsha, Hunan, China
The First People's Hospital of Changzhou
🇨🇳Changzhou, Jiangsu, China
Changzhou Cancer Hospital
🇨🇳Changzhou, Jiangsu, China
The First Affiliated Hospital of Soochow University
🇨🇳Suzhou, Jiangsu, China
Xuzhou Central Hospital
🇨🇳Xuzhou, Jiangsu, China
The First Affiliated Hospital of Nanchang University
🇨🇳Nanchang, Jiangxi, China
The Second Affiliated Hospital of Nanchang University
🇨🇳Nanchang, Jiangxi, China
The First Affiliated Hospital of Jinzhou Medical University
🇨🇳Jinzhou, Liaoning, China
The First Hospital of China Medical University
🇨🇳Shenyang, Liaoning, China
Liaoning Cancer Hospital & Institute
🇨🇳Shenyang, Liaoning, China
Jinan Central Hospital
🇨🇳Jinan, Shandong, China
Shandong Cancer Hospital
🇨🇳Jinan, Shandong, China
LinYi Cancer Hospital
🇨🇳Linyi, Shandong, China
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
🇨🇳Shanghai, Shanghai, China
CHU Poitiers
🇫🇷Poitiers, France
Shanxi Province Cancer Hospital
🇨🇳Taiyuan, Shanxi, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
Beijing Cancer Hospital
🇨🇳Beijing, China
Hunan Cancer Hospital
🇨🇳Changsha, China
Army Specialty Medical Center of The Chinese People's Liberation Army
🇨🇳Chongqing, China
Shanghai General Hospital
🇨🇳Shanghai, China
Centre Hospitalier Regional et Universitaire de Besancon - Hopital Jean-Minjoz
🇫🇷Besancon Cedex, Other, France
Institut Sainte Catherine
🇫🇷Avignon cedex 9, France
CHU Brest Hopital Cavale Blanche
🇫🇷Brest, France
Hopital Henri Mondor
🇫🇷Creteil, France
Center Georges-Francois Leclerc
🇫🇷Dijon, France
Hopital Edouard Herriot
🇫🇷LYON Cedex 3, France
Höpital Saint-Joseph
🇫🇷Marseille CEDEX 8, France
Centre Hospitalier Universitaire Nantes-Hotel Dieu
🇫🇷Nantes Cedex 1, France
Centre Antoine Lacassagne
🇫🇷Nice cedex 2, France
Hopital Saint-Louis
🇫🇷Paris, France
Pharmacy Address:Hopital Saint-Louis
🇫🇷Paris, France
CHU de Rouen
🇫🇷ROUEN Cedex, France
Institut de Cancérologie de l'Ouest - Saint-Herblain
🇫🇷Saint Herblain, France
Centre Hospitalier Universitaire Sainte-Etienne - Hopital Nord
🇫🇷Saint Priest En Jarez, France
Institut de Cancerologie Strasbourg Europe
🇫🇷Strasbourg, France
CCC Muenchen TUM
🇩🇪Muenchen, Bavaria, Germany
LMU Klinikum - Campus Großhadern
🇩🇪München, Bayern, Germany
Regierung von Oberfranken
🇩🇪Bayreuth, Ludwigstraße, Germany
Regierungspräsidium Darmstadt
🇩🇪Darmstadt, Luisenplatz, Germany
Klinikum St. Marien Amberg
🇩🇪Amberg, Germany
Medizinische Hochschule Hannover (MHH)
🇩🇪Hannover, Germany
Universitätsklinikum Leipzig
🇩🇪Leipzig, Germany
Landesdirektion Sachsen Dienststelle Leipzig
🇩🇪Leipzig, Saxony, Germany
Charité - Universitätsmedizin Berlin
🇩🇪Berlin, Germany
Apotheke Johannstadt
🇩🇪Dresden, Germany
Gemeinschaftspraxis Hämatologie - Onkologie
🇩🇪Dresden, Germany
Technische Universität Dresden, Medizinische Fakultät Carl Gustav Carus
🇩🇪Dresden, Germany
Universitätsklinikum Carl Gustav Carus Dresden
🇩🇪Dresden, Germany
Agaplesion Frankfurter Diakonie Kliniken gGmbH
🇩🇪Frankfurt, Germany
Agaplesion Markus Krankenhaus
🇩🇪Frankfurt, Germany
Hämatologisch Onkologische Praxis Eppendorf (HOPE)
🇩🇪Hamburg, Germany
ZytoService Deutschland GmbH
🇩🇪Hamburg, Germany
Asklepios Kliniken Hamburg GmbH
🇩🇪Hamburg, Germany
Asklepios Tumorzentrum Hamburg, Asklepios Klinik Altona
🇩🇪Hamburg, Germany
Klinikum rechts der Isar der TU München, Krankenhausapotheke
🇩🇪Muenchen, Germany
Klinikum Rechts der Isar der Technischen Universitaet Muenchen
🇩🇪Munchen, Germany
Klinik für Hämatologie, Onkologie und Gastroenterologie
🇩🇪Mönchengladbach, Germany
Klinikum rechts der Isar der Technischen Universitaet Muenchen
🇩🇪München, Germany
Zentrale Apotheke - Rheinland Klinikum Lukaskrankenhaus Neuss
🇩🇪Neuss, Germany
Universitaetsklinikum Ulm
🇩🇪Ulm, Germany
Athens Medical Group Psychiko Hospital
🇬🇷Psychiko, Athens, Greece
Athens Medical Center - Psychikon branch
🇬🇷Athens, Attikí, Greece
University General Hospital "Attikon"
🇬🇷Athens, Chaidari, Greece
"University General Hospital of Heraklion Oncology Unit "
🇬🇷Heraklion, Crete, Greece
"Papageorgiou" General Hospital of Thessaloniki 2nd Internal Medicine/Oncology Clinic of Aristotle
🇬🇷Nea Efkarpia, Thessaloniki, Greece
Evgenidion Clinic Agia Trias Oncology Department
🇬🇷Athens, Greece
Athens Medical Group, Psychiko Hospital
🇬🇷Psychiko, Greece
Tolna Megyei Balassa Janos Korhaz
🇭🇺Szekszard, Hungary
Cork University Hospital,Department of Medical Onncology
🇮🇪Cork, Ireland
Bon Secours Hospital
🇮🇪Cork, Ireland
St Vincents University Hospital
🇮🇪Dublin, Ireland
Mater Misericordiae University Hospital
🇮🇪Dublin, Ireland
Mater Private Hospital
🇮🇪Dublin, Ireland
Beaumont Hospital
🇮🇪Dublin, Ireland
University Hospital Waterford
🇮🇪Waterford, Ireland
Azienda Ospedaliera Universitaria Cagliari
🇮🇹Monserrato, Cagliari, Italy
Farmacia AOU Cagliari - Presidio Ospedaliero ' Duilio Casula' di Monserrate
🇮🇹Monserrato, Cagliari, Italy
UOC Oncologia Medica - Dipartimento Onco Ematologico AORN San Giuseppe Moscati di Avellino
🇮🇹Avellino, Campania, Italy
IRCCS Ospedale Policlinico San Martino Farmacia
🇮🇹Genova, GE, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
🇮🇹Roma, Lazio, Italy
UOC Oncologia, Azienda Ospedaliera Cardinale Giovanni Panico
🇮🇹Tricase, Lecce, Italy
Fondazione Poliambulanza Istituto Ospedaliero
🇮🇹Brescia, Lombardia, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
🇮🇹Milano, Lombardy, Italy
lstituto Europeo di Oncologia
🇮🇹Milano, Lombardy, Italy
Niguarda Cancer Center Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
🇮🇹Milano, Lombardy, Italy
UMaCA U.O.S.D. Farmacia Ospedaliera
🇮🇹Napoli, Naples, Italy
IRCCS Ospedale Policlinico San Martino
🇮🇹Genova, Other, Italy
Ospedale S Chiara Farmacia
🇮🇹Pisa, Other, Italy
Servizio Farmacia Azienda Ospedaliera Universitaria lntegrata (AOUI) di Verona
🇮🇹Verona, Other, Italy
Farmacia Sperimentazioni
🇮🇹Reggio Emilia, RE, Italy
UOC Oncologia Medica, ARNAS GARIBALDI - PRESIDIO OSPEDALIERO NESIMA
🇮🇹Catania, Sicily, Italy
Azienda Ospedaliero Universitaria Pisana
🇮🇹Pisa, Toscana, Italy
SODc Oncologia Medica e Clinica, AOU Careggi
🇮🇹Firenze, Tuscany, Italy
Istituto Oncologico Veneto - IRCCS
🇮🇹Padova, Veneto, Italy
Struttura Semplice Dipartimentale di Oncologia Medica e Terapia Biomolecolare Azienda Ospedaliero
🇮🇹Foggia, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori Farmacia
🇮🇹Milano, Italy
lstituto Europeo di Oncologia Servizio Farmacia
🇮🇹Milan, Italy
Istituto Oncologico Veneto-IRCCS Farmacia
🇮🇹Padova, Italy
Fondazione IRCCS Policlinico San Matteo Farmacia
🇮🇹Pavia, Italy
Fondazione IRCCS Policlinico San Matteo
🇮🇹Pavia, Italy
Farmacia UFA
🇮🇹Reggio Emilia, Italy
S.C Oncologia Arcispedale Santa Maria Nuova
🇮🇹Reggio Emilia, Italy
Farmacia degli Sperimentali Policlinico Gemelli IRCCS
🇮🇹Roma, Italy
ASST della Valtellina e dell'alto Lario - Presidio Ospedaliero di Sondrio
🇮🇹Sondrio, Italy
ASST della Valtellina e dell'alto Lario- Presidio Ospedaliero di Sondrio Farmacia
🇮🇹Sondrio, Italy
U.O.C. Oncologia Azienda Ospedaliera Universitaria lntegrata (AOUI) di Verona
🇮🇹Verona, Italy
Chiba Cancer Center
🇯🇵Chiba-shi, Chiba-ken, Japan
National Cancer Center Hospital East
🇯🇵Kashiwa-shi, Chiba-ken, Japan
NHO Shikoku Cancer Center
🇯🇵Matsuyama-shi, Ehime-ken, Japan
National Hospital Organization Kyushu Cancer Center
🇯🇵Fukuoka-City, Fukuoka, Japan
Hokkaido University Hospital
🇯🇵Sapporo, Hokkaido, Japan
Kobe City Hospital Organization Kobe City Medical Center General Hospital
🇯🇵Kobe-shi, Hyōgo, Japan
Kagawa University Hospital
🇯🇵Kita-gun, Kagawa, Japan
St. Marianna University Hospital
🇯🇵Kawasaki-shi, Kanagawa, Japan
Kanagawa Cancer Center
🇯🇵Yokohama-shi, Kanagawa, Japan
Osaka University Hospital
🇯🇵Suita-shi, Osaka-fu, Japan
National Hospital Organization Osaka National Hospital
🇯🇵Chuo-Ku, Osaka, Japan
Osaka General Medical Center
🇯🇵Osaka-shi, Osaka, Japan
Kindai University Hospital
🇯🇵Osakasayama-shi, Osaka, Japan
Osaka Medical and Pharmaceutical University Hospital
🇯🇵Takatsuki-shi, Osaka, Japan
Saitama Cancer Center
🇯🇵Kitaadachi-gun, Saitama, Japan
National Cancer Center Hospital
🇯🇵Chuo-Ku, Tokyo, Japan
Cancer Institute Hospital of JFCR
🇯🇵Koto-ku, Tokyo, Japan
Gachon University Gil Medical Center
🇰🇷Incheon, Korea, Republic of
Korea University Anam Hospital
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Korea University Guro Hospital
🇰🇷Seoul, Korea, Republic of
St. Antonius Hospital
🇳🇱Nieuwegein, Other, Netherlands
Netherlands Cancer Institute
🇳🇱Amsterdam, Netherlands
Het Nederlands Kanker Instituut
🇳🇱Amsterdam, Netherlands
Klinische Farmacie
🇳🇱Nieuwegein, Netherlands
St. Antonius Ziekenhuis - Ziekenhuis Utrecht
🇳🇱Utrecht, Netherlands
Viecuri Medisch Centrum
🇳🇱Venlo, Netherlands
Sjukehusapoteket i Bergen [Bergen Hospital Pharmacy]
🇳🇴Bergen, Norway
Helse Bergen HF, Haukeland University Hospital
🇳🇴Bergen, Norway
Oslo University Hospital (OUH) - The Norwegian Radium Hospital
🇳🇴Oslo, Norway
Sykehusapoteket Oslo, Radiumhospitalet - Avdeling Produksjon
🇳🇴Oslo, Norway
Narodowy lnstytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy lnstytut Badawczy
🇵🇱Warszawa, Mazowieckie, Poland
Marii Sklodowskiej-Curie Panstwowy lnstytut Badawczy
🇵🇱Warszawa, Mazowieckie, Poland
MRUK-MED | Sp. z.o.o Apteka szpitalna
🇵🇱Rzeszow, Podkarpackie, Poland
MRUK-MED | Sp. z.o.o
🇵🇱Rzeszow, Podkarpackie, Poland
Apteka Szpitalna Uniwersytie Centrum Kliniczne
🇵🇱Gdansk, Pomorskie, Poland
Przychodnia Lekarska KOMED Roman Karaszewski
🇵🇱Konin, Wielkopolskie, Poland
Salve Medica Apteka Szpitalna
🇵🇱Lodz, Poland
Hospital Garcia de Orta
🇵🇹Almada, Portugal
Unidade Local de Saude da Guarda-Hospital Sousa Martins
🇵🇹Guarda, Portugal
Fundacao Champalimaud
🇵🇹Lisboa, Portugal
Centro Hospitalar Universitário de Santo Antonio,E.P.E.
🇵🇹Porto, Portugal
Narodny Onkologicky ustav II.Onkologicka Klinika LFUK a NOU
🇸🇰Bratislava, Slovakia
Hospital Duran i Reynals - Institut Catala d'Oncologia L'Hospitalet (ICO L'Hospitalet)
🇪🇸L'Hospitalet de Llobregat, Barcelona, Spain
CETIR Viladomat
🇪🇸Barcelona, Other, Spain
Hospital General Universitario de Alicante
🇪🇸Alicante, Spain
Radiology: CETIR Ascires
🇪🇸Barcelona, Spain
Data review: Vall d'Hebron institute of Oncology (VHIO).
🇪🇸Barcelona, Spain
Hospital Vall d'Hebron Unidad de Farmacia de Ensayos Clinicos Oncohematologia
🇪🇸Barcelona, Spain
Hospital Vall d'Hebron
🇪🇸Barcelona, Spain
Hospital Clinic de Barcelona
🇪🇸Barcelona, Spain
Hospital Universitario Reina Sofia
🇪🇸Cordoba, Spain
Hospital Universitari Arnau de Vilanova
🇪🇸Lleida, Spain
Hospital General Universitario Gregorio Maranon
🇪🇸Madrid, Spain
Hospital Universitario Ramon y Cajal
🇪🇸Madrid, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Hospital Regional Universitario de Malaga (Hospital Civil)
🇪🇸Malaga, Spain
Complejo Hospitalario Universitario de Ourense
🇪🇸Ourense, Spain
Hospital Universitario Central de Asturias
🇪🇸Oviedo, Spain
Complejo Hospitalario de Navarra
🇪🇸Pamplona, Spain
Hospital Universitario Marques de Valdecilla
🇪🇸Santander, Spain
Hospital Universitario Virgen del Rocio
🇪🇸Sevilla, Spain
Hospital General Universitario de Valencia
🇪🇸Valencia, Spain
Hospital Quiron Salud Zaragoza
🇪🇸Zaragoza, Spain
Hospital Universitario Miguel Servet
🇪🇸Zaragoza, Spain
Pharmacy:Kantonsspital Winterthur
🇨🇭Winterthur, Other, Switzerland
Zuripharm AG
🇨🇭Schlieren, Switzerland
Kantonsspital Winterthur
🇨🇭Winterthur, Switzerland
Universitatsspital Zurich - Klinik fur Medizinische Onkologie und Hamatologie USZ
🇨🇭Zurich, Switzerland
Kaohsiung Chang Gung Memorial Hospital
🇨🇳Kaohsiung City, Taiwan
National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan
National Cheng-Kung University Hospital
🇨🇳Tainan, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
National Taiwan University Hospital Clinical Trial Pharmacy
🇨🇳Taipei, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Chang Gung Memorial Hospital LinKou
🇨🇳Taoyuan, Taiwan
Cambridge University Hospitals NHS Foundation Trust
🇬🇧Cambridge, Cambridgeshire, United Kingdom
The Newcastle upon Tyne Hospitals NHS Foundation Trust
🇬🇧Newcastle Upon Tyne, United Kingdom
Cambridge University Hospitals NHS Foundation Trust, Oncology Centre
🇬🇧Cambridge, England, United Kingdom
The Royal Marsden Hospital
🇬🇧Sutton, Surrey, United Kingdom
Leeds Teaching Hospitals Trust
🇬🇧Leeds, WEST Yorkshire, United Kingdom
University Hospitals Bristol and Weston NHS Foundation Trust
🇬🇧Bristol, United Kingdom
Leeds Teaching Hospitals NHS Trust, st James's Institute of Oncology
🇬🇧Leeds, United Kingdom
Guy's and Saint Thomas' NHS Foundation Trust
🇬🇧London, United Kingdom
Guy's and St Thomas' NHS Foundation
🇬🇧London, United Kingdom
The Royal Marsden Hospital - Chelsea Site
🇬🇧London, United Kingdom
Imperial College Healthcare NHS Trust
🇬🇧London, United Kingdom
The Christie NHS Foundation Trust
🇬🇧Manchester, United Kingdom