Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells
- Conditions
- Pediatric Cancer
- Interventions
- Other: Collection of post mortem tissue donation
- Registration Number
- NCT05120518
- Brief Summary
The objective of this study is to utilize all donated pediatric tumor tissues and cells obtained from autopsy to prospectively develop novel patient derived orthotopic xenograft (PDOX) mouse models as well as in vitro cell culture model systems for pediatric cancers, and also provide tissue samples to other researchers and organizations (eg, CBTN, DIPG Registry, COG).
- Detailed Description
The objective of this study is to utilize all donated pediatric tumor tissues and cells obtained from autopsy to prospectively develop novel patient derived orthotopic xenograft (PDOX) mouse models as well as in vitro cell culture model systems for pediatric cancers, and also provide tissue samples to other researchers and organizations (eg, CBTN, DIPG Registry, COG).
This model system will then be subjected to 1) comprehensive histopathological and molecular characterizations during serial in vivo sub-transplantations; 2) cryopreserved for long term preservation of tumorigenicity; and 3) used for future biological studies and preclinical drug testing.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 150
- Pediatric patients with cancer and non-cancer tumor types (solid, liquid, neuro-oncology)
- Signed consent for post mortem tissue donation and autopsy
- Signed consent for post mortem tissue donation and autopsy not obtained
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Pediatric patients with cancer and non-cancer tumor types Collection of post mortem tissue donation Pediatric patients with cancer and non-cancer tumor types (solid, liquid, neuro-oncology and stem cell)
- Primary Outcome Measures
Name Time Method Procurement of pediatric cancer and non-cancer tumor tissue during autopsy with signed consent Up to 5 years from procurement Procurement of pediatric cancer and non-cancer tumor tissue during autopsy with signed consent. Tissue will be collected through a research tissue collection autopsy of the original tumor and other sites that are appropriate. Samples of both tumor and normal cells will be collected in addition to body fluids such as cerebrospinal fluid (CSF), blood, bone marrow, and skin biopsies for genomic testing.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Ann & Robert H. Lurie Children's Hospital of Chicago
🇺🇸Chicago, Illinois, United States