Effect of Short-term Oxygen During CPET in Pulmonary Hypertension

Phase 2

Completed

• Conditions: Chronic Cardiorespiratory Disease; Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension
• Interventions: Procedure: Supplemental oxygen via a mask

• Registration Number: NCT01748474
• Lead Sponsor: University of Zurich

Brief Summary

In a randomized, sham-controlled trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with pulmonary arterial or chronic thromboembolic pulmonary hypertension.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2012-10-04
• Study Start: 2012-12
• Study First Submitted QC: 2012-12-11
• Study First Posted: 2012-12-12
• Primary Completion: 2016-03
• Study Completion: 2016-07
• Status Verified: 2016-08
• Last Update Submitted: 2016-08-11
• Last Update Posted: 2016-08-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Sham room air	Supplemental oxygen via a mask	Room air will be applied similarly to oxygen
Supplemental oxygen	Supplemental oxygen via a mask	Supplemental oxygen will be applied via a mask during CPET

Primary Outcome Measures

Name	Time	Method
Watt	1 day
exercise time	1 day

Secondary Outcome Measures

Name	Time	Method
Peak oxygen uptake	1 day
Respiratory exchange ratio	1 day
ventilatory equivalent of carbon dioxide (VE/VCO2) slope	1 day
end-tidal pressures of carbon dioxide (PET CO2)	1 day
Changes in arterial blood parameters	1 day

Trial Locations

Locations (1)

University Hospital Zurich, Division of Pneumology; 🇨🇭 Zurich, ZH, Switzerland