Pharmacokinetics and Pharmacodynamics of a 100 mg Caffeine Dose After Oral Consumption of an Energy Drink or Inhalation Using the Aeroshot Administration Device
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Caffeine plasma concentration
研究概览
简要总结
The purpose of this study is to determine how fast caffeine gets into your body with a product called Aeroshot™. Aeroshot™ is a lipstick sized device that you slide open and then put your mouth over the opening and inhale. A fine powder containing 100 mg of caffeine is deposited on your tongue and the inside of your mouth. Caffeine will be absorbed through the membranes in your mouth or swallowed and then absorbed in your stomach. We will compare the absorption of caffeine after using the Aeroshot™ with the absorption after drinking an energy drink by taking 15 blood samples over 8 hours and measuring the caffeine levels in your blood. You will also be asked to fill out some scales to measure the effects you feel after the caffeine dose. We hypothesize that caffeine absorption after inhalation will be faster than after an energy drink.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 45 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy volunteer
- •non-smoker
排除标准
- •Take chronic medication
- •Co-existing diseases
- •Platelet count less than 100,000/uL (per microliter)
- •Acute or chronic psychiatric condition
- •Consume more than 300 mg of caffeine per day
- •Participated in another study within last 30 days or donated blood in last 6 weeks
研究组 & 干预措施
Aeroshot
A single 100 mg caffeine dose administered using the Aeroshot device.
干预措施: Caffeine (Dietary Supplement)
Energy Drink
A single 100 mg caffeine dose administered as an oral solution.
干预措施: Caffeine (Dietary Supplement)
结局指标
主要结局
Caffeine plasma concentration
时间窗: 0, 1, 2, 5, 10, 15, 20, 30, 40, 60 minutes and 2, 3, 4, 6, 8 hours
These are the collection times of blood samples relative to when the caffeine dose was consumed.
次要结局
- Caffeine effects(0, 1, 2, 5, 10, 15, 20, 30, 40, 60 minutes, and 2, 3, 4, 6, 8 hours)
