Dietary factors that affect kidney function
- Conditions
- Age and gender matched healthy individuals will be selected as control. Their health status will be ascertained by sign and symptoms of healthy person mentioned in Khila sthana of Kashyapa SamhitaChronic kidney disease, unspecified,
- Registration Number
- CTRI/2022/01/039474
- Lead Sponsor
- Institute of Teaching and Research in Ayurveda Ministry of Ayush
- Brief Summary
Present work is a case control study for which 62 subjectshad been recruited in each group to assess the possible causes of CKDespecially in context of *Rakta- Meda* vitiating diet. In case group,diagnosed patients of CKD in accordance with KDIGO criteria, age ≥20 yrs. andchronicity ≤1 yr. were enrolled. Whereas in control group age and gendermatched healthy individuals were selected. A closed ended questionnairecontaining demographic details, potential dietary and lifestyle factors on thebasis of classics and relevant examinations was prepared and used for datacollection. Forcase subjects, already carried out laboratory investigations (to diagnoseCKD) had beendocumented. However, in control group hemoglobin, complete blood count, fastingblood sugar, lipid profile, renal profile, urine routine and microscopic investigationswere carried out to rule out any metabolic and renal diseases.
Obtained data from survey of case andcontrol groups had been presented in tabular form and statistical tests such aschi square, odds ratio, confidence interval (CI) and logistic regressionanalysis were applied and interpreted. In this study, maximum participants observedwere of age group 61-70 yrs. (case and control- 30.64% each), male (case andcontrol- 59.67% each), Hindu (case-88.7%, control- 96.77%), married (case- 88.7%,control- 91.93%), urban resident (case- 80.64%, control- 91.93%), *JangalaDesha* (case- 98.38%, control- 100%), secondary education (case- 35.48%,control- 22.58%), housewife (case- 37.09%, control- 32.25%), lower middle andmiddle class (case- 45.16% each, control- 17.74% and 80.64% respectively),insidious onset of disease (case- 61.29%), diabetic (case- 43.54%),hypertensive (case- 80.64%), positive family history of typeâ…¡ DM(case- 20.96%, control- 4.83%) and HTN (case- 16.12%, control- 6.45%).
On comparingthe probable causative factors from case and control groups following remainedhighly significant or significant: 1) ***Rakta* vitiating factors**- Frequentor regular intake of black gram (p - 0.0405), food that cause burning sensation(p - 0.0162), food that is sharp in nature (p - 0.0028), salty food (p -0.0063) and mid-day sun exposure (p - 0.0212) were observed. 2) ***Meda* vitiating factors**- Frequentor regular intake of non-veg diet (p -0.0006), *Guru Guna* dominant diet(p - 0.0000), deep fried food (p - 0.0000), fine flour products (p - 0.0055),buffalo or full fat milk (p - 0.0102), curd (p - 0.0027), fish (p - 0.0209) andpositive family history of type â…¡ diabetes mellitus (p - 0.0135)were found.
Basedon this study it can be concluded that, as kidney is formed by *Rakta* and*Meda Dhatu,* dietary and lifestyle factors vitiating them can contributeto development, manifestation and progression of CKD. Therefore, nullhypothesis is rejected and alternative hypothesis i.e., there is positive association between *Rakta- Meda*vitiating diet and CKD is accepted.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 200
Diagnosed patients of CKD with chronicity less than or equal to 1 yr, Patients of age more than or equal to 20 yrs, Patients willing to participate and follow study protocol.
Patients of age less than 20 yrs, Patients not willing to abide by study protocol.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Association between Rakta - Meda vitiating diet/activities and CKD one day
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Institute of Teaching and Research in Ayurveda
🇮🇳Jamnagar, GUJARAT, India
Institute of Teaching and Research in Ayurveda🇮🇳Jamnagar, GUJARAT, IndiaAnjali sainiPrincipal investigator9999026071anjalisaini9691@gmail.com