NL-OMON47369已完成不适用
Imaging activated microglia in relapsing remitting multiple sclerosis: a first in human P2X7r PET study - M1MS
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •- For the MS patient group: diagnosis of relapsing remitting MS with clinically or radiologically active disease
- •- 20 to 60 years old
- •- Written informed consent
排除标准
- •- Current or recent immunomodulating or immunosuppressive therapy, excluding first-line MS treatment started less than 3 months prior to the PET-scans.
- •- Inability to undergo MRI and PET scan (metal objects in or around the body, claustrophobia or inability to lie still in the scanner) and for the patient group contra-indication for gadolinium administration
- •- Significant immune disease other than MS
- •- (History of) other relevant neurological disease
- •- Known allergy including, but not limited to, hay fever, dust mite allergy and allergies to cats or dogs
- •- Known asthma
- •- History of malignancy
- •- Known significant cardiac disease
- •- Inadequate renal function: creatinine clearance <60 ml/min
- •- In male subjects Hb <8.0 g/dL, in female subjects Hb <7.0 g/dL
- •- Pregnant or breast feeding
- •- (History of) alcohol and/or drug abuse
- •- Exposure to previous radiation leading to annual cumulative dose of more than 10 mSV if participating in this protocol
研究者
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