Recurrent Embryo Implantation Failure in Women Undergoing IVF/ ICSI; an Investigation of the Intra-Uterine Environment During the Window of Implantation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- UMC Utrecht
- 入组人数
- 80
- 试验地点
- 1
研究概览
简要总结
We will investigate maternal and embryonic factors in women with recurrent implantation failure, undergoing IVF/ ICSI treatment. Women who have not achieved a pregnancy after three embryo transfer procedures will undergo an endometrial biopsy during the window of implantation in a natural cycle. During the next treatment cycle we will aspirate endometrial secretion and perform a doppler ultrasound investigation of the a. uterina. Moreover, we will investigate the cytokine expression from the transferred embryo from the culture medium.
详细描述
Rationale:
Despite advances in IVF procedures and the transfer of embryos of high morphological quality embryos, pregnancy rates from IVF remain around 30% per embryo transfer procedure. Failure of the transferred embryo to implant remains the most important limiting factor determining in vitro fertilization (IVF) or intra cytoplasmic sperm injection (ICSI) success rates. If progress is to be made in improving implantation rates, a greater understanding of the factors which determine successful implantation is required. Recurrent implantation failure after IVF may be due to an endometrial, and embryo problem or both. All women entering our IVF program undergo pre-conceptional counseling and a pre-treatment blood withdrawal for hormonal investigation and investigation of uterine cavity by ultrasound examination, hysteroscopy and endometrial biopsy. The data generated by this pre-treatment screening potentially enables factors predictive of implantation failure to be identified. In addition, study of the further IVF cycle will increase our knowledge of the factors of endometrial and embryo factors involved in implantation failure, and aid in the characterization of the different causes of this distressing clinical problem. On the basis of these data, rational interventions designed to improve outcome can be designed and tested.
Objective:
To delineate pre-treatment predictors of recurrent implantation failure, to characterize the different phenotypes of women suffering from this problem and to study the relative importance of maternal and embryonic causes of implantation failure.
Study design:
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 37 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Women who have not achieved a pregnancy, despite 3 subsequent embryo transfers, of which only one is allowed to be a transfer of a cryo-thawed embryo. A chemical pregnancy or E.U.G. will not be regarded as a pregnancy. An abortion will be regarded as a pregnancy.
排除标准
- •women older than 37 years.