Investigation of the Effects of Minimal and High Flow Anesthesia on Thiol Disulfide Balance and Peripheral Tissue Saturation (StO2) in Hypotensive Anesthesia Applications
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Oxidative Stress
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- Thiol Disulfide Balance
- Last Updated
- 7 years ago
Overview
Brief Summary
The effects of Minimal Flow Anesthesia (0.4 l / min) and High Flow Anaesthesia (2 l / min) on tissue oxygen saturation (St02) and thiol / disulfide balance in hypotensive anesthesia operations will be investigated.
Detailed Description
The oxidative stress at the cellular level and the possible effects of general anesthesia techniques on the antioxidant system make the method of anesthesia more important. The effects of Minimal Flow Anesthesia (0.4 l / min) and High Flow Anaesthesia (2 l / min) on tissue oxygen saturation (St02) and thiol / disulfide balance in hypotensive anesthesia operations will be investigated. Minimal flow anesthesia is widely used because of its advantages such as cost reduction, prevention of environmental pollution, minimization of heat and humidity loss. Hypotensive anesthesia is preferred in some specialized surgical procedures in order to reduce bleeding and improve the surgical field of view. The use of hypotensive anesthesia and inhalation agents may cause hypoperfusion at the tissue level and cause hypoxia-induced oxidative stress and initiate cell damage. Determining the ideal anesthesia technique in terms of oxidative stress and tissue perfusion will reduce intra- and postoperative risks by protecting patients from the harmful effects of anesthesia.
Investigators
Şule Batçık
Assistant Professor
Recep Tayyip Erdogan University Training and Research Hospital
Eligibility Criteria
Inclusion Criteria
- •ASA (American Society of Anesthesiologists) I tympanoplasty operations with hypotensive anesthesia,
- •ASA (American Society of Anesthesiologists) II tympanoplasty operations with hypotensive anesthesia,
Exclusion Criteria
- •operations in less than one hour
- •uncontrolled hypertension
- •DM (Diabetes Mellitus)
- •cerebrovascular disease
- •coagulopathy
- •morbid obesity ((BMI ≥ 35)
- •renal disease
Outcomes
Primary Outcomes
Thiol Disulfide Balance
Time Frame: For two groups; First blood sample will be taken 30 min before the start of surgery, second blood sample will be taken at the 60th min of the surgery
Change of Oxidative Stress Marker
Secondary Outcomes
- StO2(For two groups; simultaneously, 30 min before the start of surgery, 60th min of the surgery)