Effects of Minimal and High Flow Anesthesia on Thiol Disulfide Balance and StO2 in Hypotensive Anesthesia Applications

Not Applicable

• Conditions: Oxidative Stress

• Registration Number: NCT03563833
• Lead Sponsor: Recep Tayyip Erdogan University Training and Research Hospital

Brief Summary

The effects of Minimal Flow Anesthesia (0.4 l / min) and High Flow Anaesthesia (2 l / min) on tissue oxygen saturation (St02) and thiol / disulfide balance in hypotensive anesthesia operations will be investigated.

Detailed Description

The oxidative stress at the cellular level and the possible effects of general anesthesia techniques on the antioxidant system make the method of anesthesia more important.

The effects of Minimal Flow Anesthesia (0.4 l / min) and High Flow Anaesthesia (2 l / min) on tissue oxygen saturation (St02) and thiol / disulfide balance in hypotensive anesthesia operations will be investigated.

Minimal flow anesthesia is widely used because of its advantages such as cost reduction, prevention of environmental pollution, minimization of heat and humidity loss.

Hypotensive anesthesia is preferred in some specialized surgical procedures in order to reduce bleeding and improve the surgical field of view.

The use of hypotensive anesthesia and inhalation agents may cause hypoperfusion at the tissue level and cause hypoxia-induced oxidative stress and initiate cell damage.

Determining the ideal anesthesia technique in terms of oxidative stress and tissue perfusion will reduce intra- and postoperative risks by protecting patients from the harmful effects of anesthesia.

Study Timeline

• Study Start: 2018-05-04
• Study First Submitted: 2018-05-20
• Status Verified: 2018-06
• Study First Submitted QC: 2018-06-19
• Last Update Submitted: 2018-06-19
• Study First Posted: 2018-06-20
• Last Update Posted: 2018-06-20
• Primary Completion: 2018-10-31
• Study Completion: 2018-11-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• ASA (American Society of Anesthesiologists) I tympanoplasty operations with hypotensive anesthesia,
• ASA (American Society of Anesthesiologists) II tympanoplasty operations with hypotensive anesthesia,

Exclusion Criteria

• operations in less than one hour
• uncontrolled hypertension
• DM (Diabetes Mellitus)
• cerebrovascular disease
• coagulopathy
• morbid obesity ((BMI ≥ 35)
• renal disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Thiol Disulfide Balance	For two groups; First blood sample will be taken 30 min before the start of surgery, second blood sample will be taken at the 60th min of the surgery	Change of Oxidative Stress Marker

Secondary Outcome Measures

Name	Time	Method
StO2	For two groups; simultaneously, 30 min before the start of surgery, 60th min of the surgery	Change of Peripheral Tissue Oxygen Saturation

Trial Locations

Locations (1)

Recep Tayyip Erdoğan University Training and Research Hospital; 🇹🇷 Rize, Turkey