Assessing Lung Dynamics and Respiratory Functions in Minimal Flow Anesthesia: A Prospective Study

Not Applicable

Completed

• Conditions: Medium Flow Anesthesia; Minimal Flow Anesthesia; Pulmonary Function Test; Peak Inspiratuar Pressure; Compliance, Patient
• Interventions: Other: Medium flow anesthesia; Other: Minimal flow anesthesia

• Registration Number: NCT06055335
• Lead Sponsor: Ataturk University

Brief Summary

The patients were randomized into two groups medium flow anesthesia (MeFA) and minimal flow anesthesia (MiFA). While MeFA received medium flow anesthesia with 2 lt/min, MiFA received minimal flow anesthesia with 0.5 lt/min fresh gas flow. In both groups dynamic compliance values, peak inspiratory pressure (PIP) values, total inhalation anesthetic drug consumption, total remifentanil drug consumption, duration of anesthesia, and duration of surgery were recorded. The FVC, FEV1, and FEV1/FVC values of the patients in both groups were evaluated and noted 24 hours before the operation, after the operation 2nd, 8th, and 24th hours.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-06-02
• Primary Completion: 2022-03-25
• Study Completion: 2022-04-27
• Status Verified: 2023-09
• Study First Submitted: 2023-09-14
• Study First Submitted QC: 2023-09-20
• Last Update Submitted: 2023-09-20
• Study First Posted: 2023-09-26
• Last Update Posted: 2023-09-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• ASA I-II
• 18-65 years of age, who will undergo elective laparoscopic cholecystectomy surgery

Exclusion Criteria

• ASA III-IV
• Smokers
• Body mass index (BMI) > 40 kg / m2,
• Patients with cardiovascular system disease
• Chronic respiratory diseases,
• Patients whose pulmonary function tests cannot be applied and who have problems with pulmonary function tests during the examination of the chest disease consultant

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Medium flow anesthesia	Medium flow anesthesia	After reaching the MAC 1 value with 4lt/min 50% O2 - 50% air and 8% desflurane medium flow anesthesia was started with 2 lt/min 50% O2 - 50% air with MAC 1 concentration desflurane.
Minimal flow anesthesia	Minimal flow anesthesia	After reaching the MAC 1 value with 4 lt/min 50% O2 - 50% air and 8% desflurane minimal flow anesthesia was started with 0.50 lt/min 50% O2 - 50% air with MAC 1 concentration of desflurane.

Primary Outcome Measures

Name	Time	Method
Dynamic Compliance assessment	immediately after the end of the surgical suturing	Dynamic Compliance will be assessed immediately after the end of the surgical suturing
Peak inspiratory pressure assessment	immediately after the end of the surgical suturing	Peak inspiratory pressure will be assessed immediately after the end of the surgical suturing

Secondary Outcome Measures

Name	Time	Method
FEV1 measures assessment	24th hour after the operation	FEV1 measures assessment will be assessed 24th hours after the operation
FVC measures assessment	24th hour after the operation	FVC measures assessment will be assessed 24th hours after the operation
FEV1/FVC measures assessment	24th hour after the operation	FEV1/FVC measures assessment will be assessed 24th hour after the operation
FEV1 measures assessmentt	8th hour after the operation	FEV1 measures assessment will be assessed 8th hours after the operation

Trial Locations

Locations (1)

Erkan Cem ÇELİK; 🇹🇷 Erzurum, Turkey